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Construction of 6-thioguanine and 6-mercaptopurine carriers based on βcyclodextrins and gold nanoparticles.
TLDR
This modification increased their solubility and improved their stability, betting by a site-specific transport due to their nanometric dimensions, among other advantages, and the in vitro permeability of the ternary systems was studied. Expand
Phosphoethanolamine addition to the Heptose I of the Lipopolysaccharide modifies the inner core structure and has an impact on the binding of Polymyxin B to the Escherichia coli outer membrane.
TLDR
Experimental and theoretical assays indicate that pEtN-HeptI addition promote an LPS conformational rearrangement, that could act as a shield by hindering the accession of PolB to inner LPS-targets moieties. Expand
l-Malate (−2) Protonation State is Required for Efficient Decarboxylation to l-Lactate by the Malolactic Enzyme of Oenococcus oeni
TLDR
Molecular dynamics and MM/GBSA results suggest that only MAL2− displays an extended open conformation at the binding pocket, satisfying the geometrical requirements for Mn2+ coordination, a critical component of MLE activity. Expand
A method for characterizing the thermal stability and antimicrobial binding to Lipopolysaccharides of Gram-negative isogenic mutant strains
TLDR
A method that uses Differential Scanning Calorimetry (DSC) to characterize homogeneity artificial vesicles of LPS (LPS-V) extracted from isogenic mutant bacterial strains before analyzing the antimicrobial binding by ITC is shown. Expand
Theoretical and Experimental Insights into Lipopolysaccharides-Polymyxin B Interactions Using Genetically Modified Enterobacterial Strains
The Gram-negative Outer Membrane Lipopolysaccharides (LPS) is the first molecular barrier of the antimicrobial peptide (AMP). Each LPS monomer is composed of a lipid-A and a polysaccharide chain ofExpand