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Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.
The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due to its binding to and inhibition of the catalytic activity of telomerase, an enzyme that is highly expressed inExpand
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Sports audio segmentation and classification
We present a system for audio segmentation and classification, which can segment and classify the sports audio stream into speech, non-speech very well. Expand
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Cancer immunotherapy targeting the telomerase reverse transcriptase.
The human telomerase reverse transcriptase (hTERT) is expressed in more than 85% of tumor cells but is usually not found in normal cells, which makes hTERT as an ideal tumor-associate antigen (TAA)Expand
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The new environment model building method of penetration mission based on the artificial potential field approach
This paper proposed a new penetration route planning method for UAV by improving the APF (Artificial Potential Field) for robot path planning. Expand
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A novel glioblastoma cancer gene therapy using AAV-mediated long-term expression of human TERT C-terminal polypeptide
Glioblastoma multiforme is the most aggressive form of human brain tumor, which has no effective cure. Previously, we have demonstrated that overexpression of the C-terminal fragment of the humanExpand
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Development of recombinant adeno-associated virus and adenovirus cocktail system for efficient hTERTC27 polypeptide-mediated cancer gene therapy
The low in vivo transduction efficiency of recombinant adeno-associated virus (rAAV) and the undesirably strong immunogenicity of adenovirus (rAdv) have limited their clinical utilization in cancerExpand
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Nucleolar localization of TERT is unrelated to telomerase function in human cells
Telomerase maintains telomere length and has been implicated in both aging and carcinogenesis of human cells. This enzyme is a specialized ribonucleoprotein (RNP) complex, minimally consisting of twoExpand
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Ectopic expression of a COOH-terminal fragment of the human telomerase reverse transcriptase leads to telomere dysfunction and reduction of growth and tumorigenicity in HeLa cells.
The COOH-terminus of telomerase reverse transcriptase (hTERT) has been shown to participatein the nuclear translocation of TERT. Here, we constructed plasmids expressing the COOH-terminal M(r) 27,000Expand
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Mechanochemical mineralization of “very persistent” fluorocarbon surfactants ‒ 6:2 fluorotelomer sulfonate (6:2FTS) as an example
Fluorinated organic chemicals have a wide variety of industrial and consumer applications. For long time perfluorooctane sulfonate and perfluorooctanoic acid have been used as precursors forExpand
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Distributed group consensus for heterogeneous multi-agent systems
A class of distributed control protocol is proposed for achieving the group consensus of heterogeneous multi-agent systems by using the neighbors' information. Expand
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