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- Publications
- Influence
Enamel Formation and Amelogenesis Imperfecta
- J. Hu, Y. Chun, Turki Al Hazzazzi, J. Simmer
- Biology, Medicine
- Cells Tissues Organs
- 1 July 2007
Dental enamel is the epithelial-derived hard tissue covering the crowns of teeth. It is the most highly mineralized and hardest tissue in the body. Dental enamel is acellular and has no physiological… Expand
Functions of KLK4 and MMP-20 in dental enamel formation
- Yuhe Lu, P. Papagerakis, Y. Yamakoshi, J. Hu, J. D. Bartlett, J. Simmer
- Chemistry, Medicine
- Biological chemistry
- 1 June 2008
Abstract Two proteases are secreted into the enamel matrix of developing teeth. The early protease is enamelysin (MMP-20). The late protease is kallikrein 4 (KLK4). Mutations in MMP20 and KLK4 both… Expand
Dentin Sialophosphoprotein Is Processed by MMP-2 and MMP-20 in Vitro and in Vivo*
- Y. Yamakoshi, J. Hu, T. Iwata, K. Kobayashi, M. Fukae, J. Simmer
- Chemistry, Medicine
- Journal of Biological Chemistry
- 15 December 2006
Dentin sialophosphoprotein (DSPP) is a major secretory product of odontoblasts and is critical for proper tooth dentin formation. During dentinogenesis, DSPP is proteolytically cleaved into smaller… Expand
Enamelin and autosomal-dominant amelogenesis imperfecta.
- J. Hu, Y. Yamakoshi
- Biology, Medicine
- Critical reviews in oral biology and medicine…
- 1 November 2003
Dental enamel forms as a progressively thickening extracellular layer by the action of proteins secreted by ameloblasts. The most abundant enamel protein is amelogenin, which is expressed primarily… Expand
Enamel Defects and Ameloblast-specific Expression in Enam Knock-out/lacZ Knock-in Mice*
Enamelin is critical for proper dental enamel formation, and defects in the human enamelin gene cause autosomal dominant amelogenesis imperfecta. We used gene targeting to generate a knock-in mouse… Expand
ENAM Mutations in Autosomal-dominant Amelogenesis Imperfecta
To date, 4 unique enamelin gene (ENAM) defects have been identified in kindreds with amelogenesis imperfecta. To improve our understanding of the roles of enamelin in normal enamel formation, and to… Expand
MMP-20 mutation in autosomal recessive pigmented hypomaturation amelogenesis imperfecta
During mammalian tooth formation, two proteinases are secreted by ameloblasts: enamelysin (MMP-20) and kallikrein-4 (KLK4). Enamelysin is the early protease. It is expressed by ameloblasts throughout… Expand
Hypomaturation Enamel Defects in Klk4 Knockout/LacZ Knockin Mice*
- J. Simmer, Yuanyuan Hu, Rangsiyakorn Lertlam, Y. Yamakoshi, J. Hu
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 6 May 2009
Kallikrein 4 (Klk4) is believed to play an essential role in enamel biomineralization, because defects in KLK4 cause hypomaturation amelogenesis imperfecta. We used gene targeting to generate a… Expand
Amelogenin p.M1T and p.W4S Mutations Underlying Hypoplastic X-linked Amelogenesis Imperfecta
Mutations in the human amelogenin gene (AMELX, Xp22.3) cause a phenotypically diverse set of inherited enamel malformations. We hypothesize that the effects of specific mutations on amelogenin… Expand
STIM1 and SLC24A4 Are Critical for Enamel Maturation
Dental enamel formation depends upon the transcellular transport of Ca2+ by ameloblasts, but little is known about the molecular mechanism, or even if the same process is operative during the… Expand