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Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects
- C. A. Guzzo, C. Furtek, +6 authors K. Lasseter
- Journal of clinical pharmacology
- 1 October 2002
Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double‐blind,… Expand
Disposition of radiolabeled imipenem and cilastatin in normal human volunteers.
- S. Norrby, J. D. Rogers, +6 authors J. Hsieh
- Chemistry, Medicine
- Antimicrobial Agents and Chemotherapy
- 1 November 1984
In the first of two successive studies, four healthy male subjects received 500 mg of 14C-labeled imipenem alone and together with 500 mg of unlabeled cilastatin sodium. In the second study, the same… Expand
Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines.
- R. J. Chen, W. S. Lee, +6 authors Y. Ho
- Biology, Medicine
- Toxicology and applied pharmacology
- 1 December 2000
Ketoconazole is an oral-antifungal agent that has been used worldwide in the treatment of some hormone-dependent human cancer. In this study, we demonstrated that ketoconazole (20 microM) induced… Expand
Simultaneous determination of tranilast and metabolites in plasma and urine using high-performance liquid chromatography.
A method has been developed for the simultaneous determination of Tranilast, N-(3',4'-dimethoxycinnamoyl)anthranilic acid (N-5'), and metabolites in plasma and urine from humans, dogs and rodents… Expand
Rapid liquid chromatographic determination of probenecid in human cerebrospinal fluid.
Neuroendocrine and neurochemical measurements in depression.
- K. Davis, L. Hollister, +6 authors P. Berger
- The American journal of psychiatry
- 1 December 1981
The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patients… Expand
Determination of the HMG-CoA reductase inhibitors simvastatin, lovastatin, and pravastatin in plasma by gas chromatography/chemical ionization mass spectrometry.
- M. J. Morris, J. D. Gilbert, J. Hsieh, B. Matuszewski, H. Ramjit, W. Bayne
- Chemistry, Medicine
- Biological mass spectrometry
A general method for the assay of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors lovastatin, pravastatin, and simvastatin in plasma has been developed and validated. The… Expand
Cerebrospinal fluid acetylcholine, choline, and senile dementia of the Alzheimer's type.
High-performance liquid chromatographic determination of tetrahydroaminoacridine in human and rat tissues using a rapid Sep-Pak C18 extraction.
DNA helicases, motors that move along nucleic acids: Lessons from the SF1 helicase superfamily
Publisher Summary This chapter focuses on the mechanistic aspects of superfamily 1 (SFl) DNA helicases. Helicases are allosteric enzymes, many of which are known to function as oligomeric assemblies.… Expand