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Safety, Tolerability, and Pharmacokinetics of Escalating High Doses of Ivermectin in Healthy Adult Subjects
Safety and pharmacokinetics (PK) of the antiparasitic drug ivermectin, administered in higher and/or more frequent doses than currently approved for human use, were evaluated in a double‐blind,Expand
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Disposition of radiolabeled imipenem and cilastatin in normal human volunteers.
In the first of two successive studies, four healthy male subjects received 500 mg of 14C-labeled imipenem alone and together with 500 mg of unlabeled cilastatin sodium. In the second study, the sameExpand
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Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines.
Ketoconazole is an oral-antifungal agent that has been used worldwide in the treatment of some hormone-dependent human cancer. In this study, we demonstrated that ketoconazole (20 microM) inducedExpand
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Simultaneous determination of tranilast and metabolites in plasma and urine using high-performance liquid chromatography.
A method has been developed for the simultaneous determination of Tranilast, N-(3',4'-dimethoxycinnamoyl)anthranilic acid (N-5'), and metabolites in plasma and urine from humans, dogs and rodentsExpand
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Rapid liquid chromatographic determination of probenecid in human cerebrospinal fluid.
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Neuroendocrine and neurochemical measurements in depression.
The authors performed dexamethasone suppression tests (DST), TRH infusions, 72-hour urine collections, and lumbar punctures on a group of male depressed patients. Approximately 60% of the patientsExpand
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Determination of the HMG-CoA reductase inhibitors simvastatin, lovastatin, and pravastatin in plasma by gas chromatography/chemical ionization mass spectrometry.
A general method for the assay of the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors lovastatin, pravastatin, and simvastatin in plasma has been developed and validated. TheExpand
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DNA helicases, motors that move along nucleic acids: Lessons from the SF1 helicase superfamily
Publisher Summary This chapter focuses on the mechanistic aspects of superfamily 1 (SFl) DNA helicases. Helicases are allosteric enzymes, many of which are known to function as oligomeric assemblies.Expand
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