• Publications
  • Influence
Testosterone Replacement in Hypogonadal Men With Type 2 Diabetes and/or Metabolic Syndrome (the TIMES2 Study)
TLDR
Over a 6-month period, transdermal TRT was associated with beneficial effects on insulin resistance, total and LDL-cholesterol, Lpa, and sexual health in hypogonadal men with type 2 diabetes and/or MetS. Expand
Efficacy and long-term tolerability of sublingual fentanyl orally disintegrating tablet in the treatment of breakthrough cancer pain
TLDR
Overall, sublingual fentanyl ODT was well-tolerated both systemically and sublingually, with 41 patients experiencing ≥1 study drug-related adverse event (AE) and long-term tolerability was well tolerated over 12 months of treatment. Expand
Efficacy and tolerability of transdermal granisetron for the control of chemotherapy-induced nausea and vomiting associated with moderately and highly emetogenic multi-day chemotherapy: a randomized,
TLDR
The GTDS provides effective, well-tolerated control of CINV associated with moderately or highly emetogenic multi-day chemotherapy and offers a convenient alternative route for delivering granisetron for up to 7 days that is as effective as oral granisettron. Expand
Sublingual administration of fentanyl to cancer patients is an effective treatment for breakthrough pain: results from a randomized phase II study
TLDR
SLF appears to be a fast, effective and well-tolerated treatment for BTP and reduced use of rescue medication and improved global assessment of treatment confirmed these differences as clinically important. Expand
A novel testosterone 2% gel for the treatment of hypogonadal males.
TLDR
Once-daily testosterone 2% gel restored levels of testosterone in more than 75% of patients, with low risk of supraphysiologic testosterone levels, and patients may find this a suitable option for TRT because of its application site and low volume. Expand
Long-term effectiveness and tolerability of sublingual fentanyl orally disintegrating tablet for the treatment of breakthrough cancer pain
TLDR
There was an increase in satisfaction with pain medication during the study, and sublingual fentanyl ODT showed an acceptable safety profile over 12 months of treatment, which was similar to that previously observed with transmucosal fentanyl. Expand
Pharmacokinetics of a granisetron transdermal system for the treatment of chemotherapy-induced nausea and vomiting
TLDR
The 52 cm 2 granisetron patch achieves a similar exposure to that of a 2 mg oral dose and provides continuous delivery of granisettron over 6 days and may have utility in treating chemotherapy-induced nausea and vomiting where prolonged drug delivery is advantageous. Expand
Pharmacokinetics and Repolarization Effects of Intravenous and Transdermal Granisetron
TLDR
GTDS was not associated with statistically or clinically significant effects on QTcF or other electrocardiographic variables, and provides useful clarification on the effect of granisetron delivered by GTDS on cardiac repolarization. Expand
Nitroglycerin 0.4% ointment vs placebo in the treatment of pain resulting from chronic anal fissure: a randomized, double-blind, placebo-controlled study
TLDR
In patients with moderate-to-severe CAF pain, NTG 0.4% ointment effectively reducedCAF pain compared with placebo, and this was the first placebo-controlled study that also controlled for the confounding effects of analgesics used to treat NTG-induced headache. Expand
Results from four pharmacokinetic studies of the granisetron transdermal system
TLDR
Findings from these four studies suggest that no GTDS dose adjustments are needed for patient age, body mass index, or tricep skinfold thickness, and should external heat be applied to the GTDS short-tem, there are unlikely to be significant adverse consequences. Expand
...
1
2
3
...