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Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans.
TLDR
It is shown that in skeletal muscle of both rodents and humans, a diet high in fat increases the H(2)O(2)-emitting potential of mitochondria, shifts the cellular redox environment to a more oxidized state, and decreases the redox-buffering capacity in the absence of any change in mitochondrial respiratory function. Expand
Effects of the amount and intensity of exercise on plasma lipoproteins.
TLDR
The highest amount of weekly exercise, with minimal weight change, had widespread beneficial effects on the lipoprotein profile, seen most clearly with the high amount of high-intensity exercise. Expand
Adaptive responses to muscle lengthening and shortening in humans.
TLDR
It is concluded that adaptations to training with maximal eccentric contractions are specific to eccentric muscle actions that are associated with greater neural adaptation and muscle hypertrophy than concentric exercise. Expand
Effect of the volume and intensity of exercise training on insulin sensitivity.
TLDR
In conclusion, physical activity encompassing a wide range of intensity and volume minimizes the insulin resistance that develops with a sedentary lifestyle, however, an exercise prescription that incorporated approximately 170 min of exercise/wk improved insulin sensitivity more substantially than a program utilizing approximately 115 min/wk, regardless of exercise intensity andVolume. Expand
Genome-wide Chromatin State Transitions Associated with Developmental and Environmental Cues
TLDR
The chromatin genome-wide in a large and diverse collection of human tissues and stem cells is mapped to yield unprecedented annotations of functional genomic elements and their regulation across developmental stages, lineages, and cellular environments. Expand
Influence of carbohydrate dosage on exercise performance and glycogen metabolism.
TLDR
Examination of the effects of ingestion of carbohydrate (CHO) solutions of 0 (WP), 6 ( CHO-6), 12 (CHO-12), and 18 g CHO/100 ml on performance and muscle glycogen use found no differences in glycogenUse or depletion patterns between the WP and the two CHO-12 trials. Expand
Effects of repeated days of intensified training on muscle glycogen and swimming performance.
TLDR
The findings of this research suggest that some swimmers may experience chronic muscular fatigue as a result of their failure to ingest sufficient carbohydrate to match the energy demands of heavy training. Expand
Lipid oxidation is reduced in obese human skeletal muscle.
TLDR
The data suggest that lesions at CPT-1 and post-CPT-1 events, such as mitochondrial content, contribute to the reduced reliance on fat oxidation evident in human skeletal muscle with obesity. Expand
Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice
TLDR
Results show redundancy in the functions of PPars α and δ as transcriptional regulators of fatty acid homeostasis and suggest that in skeletal muscle high levels of the δ-subtype can compensate for deficiency of PPARα. Expand
Adiponectin is not altered with exercise training despite enhanced insulin action.
TLDR
The data suggest that adiponectin is not a contributory factor to the exercise-related improvements in insulin sensitivity, and in contrast, in a separate group of subjects examined before and after weight loss, there was a substantial increase in adip onectin, which was accompanied by enhanced insulin action. Expand
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