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Factors associated with early remission of type I diabetes in children treated with cyclosporine.
To improve criteria for entry into future trials of immunosuppression, we enrolled 40 children with recent-onset Type I insulin-dependent diabetes in a pilot trial of cyclosporine. Twenty-sevenExpand
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A combination of HLA-DQ beta Asp57-negative and HLA DQ alpha Arg52 confers susceptibility to insulin-dependent diabetes mellitus.
Family and population studies indicate that predisposition to insulin-dependent (type I) diabetes mellitus (IDDM) is polygenic. It has been shown that the absence of the aspartic acid in position 57Expand
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A linkage disequilibrium map of the MHC region based on the analysis of 14 loci haplotypes in 50 French families
A sample of 100 individuals from 50 French families of known pedigrees were typed for 14 loci of the HLA region (DPB1, DQB1, DQA1, DRB1, DRB3, 4, 5, C4B, C4A, Bf, C2, TNFa, TNFb, B, Cw, A). LinkageExpand
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Insulin‐dependent diabetes mellitus (IDDM) in Caucasians is strongly associated with HLA‐DR3‐DQ2 and DR4‐DQ8. In order to investigate the HLA class II associations with IDDM in Algerians, we haveExpand
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A systematic study of HLA class II-beta DNA restriction fragments in insulin-dependent diabetes mellitus.
DNA restriction fragments of the genes encoding HLA class II-beta antigens were compared in 34 patients with insulin-dependent diabetes mellitus and 34 HLA-DR-matched healthy individuals.Expand
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SUMMARY A monospecific serum which recognizes antigen HL-A2 (Mac) of the HL-A system was systematically absorbed with homogenates of fresh organs of three individuals possessing this antigen. SpleenExpand
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HLA and Susceptibility to Hodgkin's Disease
Strong arguments supporting a genetic linkage between susceptibility to HD and HLA are reported. These observations are based on data from 33 multiplex case families, gathered from internationalExpand
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Mitochondrial DNA polymorphisms of a west Algerian population (Oran region).
Mitochondrial DNA codes for enzymes involved in the cellular energetic pathway. The polymorphism of this genome has been extensively analyzed for disease associations, but can also be used toExpand
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Class II HLA-DC beta-chain DNA restriction fragments differentiate among HLA-DR2 individuals in insulin-dependent diabetes and multiple sclerosis.
HLA-DR2 allele is negatively associated with insulin-dependent diabetes and positively associated with multiple sclerosis (MS). A 2.2-kilobase-pair EcoRI DNA restriction fragment detected with aExpand
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