J. Horácek

Publications288
h-index30
Citations2,934
Highly Influential Citations133
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Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression.
OBJECTIVES Ketamine and other NMDA (N-methyl-D-aspartate) antagonists produce fast-acting antidepressant-like effects, although the underlying mechanism is unclear. Furthermore, high affinity NMDA… Expand
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The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study.
BACKGROUND The goal of our study is to assess whether transcranial magnetic stimulation (rTMS) would facilitate the effect of antidepressant in OCD patients. METHOD The aim of the randomized,… Expand
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The Change of Regional Brain Metabolism (18 FDG PET) in Panic Disorder During The Treatment with Cognitive Behavioral Therapy or Antidepressants
BACKGROUND The goal of our study was to identify brain structures in patients with panic disorder (PD) that show changes in 18FDG PET during the treatment with cognitive behavioral therapy (CBT) or… Expand
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The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
Dizocilpine (MK-801; 0.3 mg/kg i.p.)-induced disruption in prepulse inhibition of the acoustic startle response (PPI) can be preferentially restored by "atypical" antipsychotics. In contrast, some… Expand
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Electroencephalographic Spectral and Coherence Analysis of Ketamine in Rats: Correlation with Behavioral Effects and Pharmacokinetics
Aims: This study was designed to evaluate the changes in EEG power spectra and EEG coherence in a ketamine model of psychosis in rats. Analyses of behavioral measurements – locomotion and… Expand
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Increased interleukin-6 and tumor necrosis factor alpha in first episode schizophrenia patients versus healthy controls.
BACKGROUND Inflammatory immune processes have been clearly implicated in the etiopathology of schizophrenia. There are, however, only limited data dealing with immune parameters in the first episode… Expand
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The double-blind sham-controlled study of high-frequency rTMS (20 Hz) for negative symptoms in schizophrenia: negative results.
The high-frequency repetitive transcranial magnetic stimulation (HF-rTMS) over the prefrontal cortex is a promising method for the treatment of negative symptoms of schizophrenia. Using double-blind… Expand
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White matter changes in first episode psychosis and their relation to the size of sample studied: A DTI study
BACKGROUND White matter abnormality has been recently proposed as a pathophysiological feature of schizophrenia (SZ). However, most of the data available has been gathered from chronic patients, and… Expand
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Increased sensitivity to the acute effects of MDMA (“ecstasy”) in female rats
Behavioral effects of +/-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) are relatively well described in humans as well as in animals. However, little is known about gender differences to the… Expand
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Psilocybin – Summary of knowledge and new perspectives
Psilocybin, a psychoactive alkaloid contained in hallucinogenic mushrooms, is nowadays given a lot of attention in the scientific community as a research tool for modeling psychosis as well as due to… Expand
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