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Serum thyrotropin concentration as a novel predictor of malignancy in thyroid nodules investigated by fine-needle aspiration.
- K. Boelaert, J. Horáček, R. Holder, J. Watkinson, M. Sheppard, J. Franklyn
- MedicineThe Journal of clinical endocrinology and…
- 1 November 2006
It is proposed that these simple clinical and biochemical factors can serve as an adjunct to FNAB in predicting risk of malignancy in individual patients, taking into account their gender, age, goiter type determined clinically, and serum TSH, was calculated.
Mechanism of Action of Atypical Antipsychotic Drugs and the Neurobiology of Schizophrenia
In the context of the neurodevelopmental disconnection hypothesis of schizophrenia, atypical antipsychotics induce neuronal plasticity and synaptic remodelling, not only in the striatum but also in other brain areas such as the prefrontal cortex and hippocampus, which may normalise glutamatergic dysfunction and structural abnormalities and affect the core pathophysiological substrates for schizophrenia.
Relationship of ketamine's antidepressant and psychotomimetic effects in unipolar depression.
- P. Šóš, M. Klirova, T. Novák, B. Kohútová, J. Horáček, T. Páleníček
- PsychologyNeuro endocrinology letters
A substantial relationship between ketamine's antidepressant and psychotomimetic effects was found, and this relationship could be mediated by the initial steps of ketamine’s action, trough NMDA receptors, shared by both ketamines' clinical effects.
Models of schizophrenia in humans and animals based on inhibition of NMDA receptors
The effect of repetitive transcranial magnetic stimulation (rTMS) on symptoms in obsessive compulsive disorder. A randomized, double blind, sham controlled study.
Low frequency rTMS administered over the left dorso-lateral prefrontal cortex during 10 daily sessions did not differ from sham rT MS in facilitating the effect of serotonin reuptake inhibitors in OCD patients.
Widespread white matter microstructural differences in schizophrenia across 4322 individuals: results from the ENIGMA Schizophrenia DTI Working Group
The present study provides a robust profile of widespread WM abnormalities in schizophrenia patients worldwide, and is believed to be the first ever large-scale coordinated study of WM microstructural differences in schizophrenia.
The Change of Regional Brain Metabolism (18 FDG PET) in Panic Disorder During The Treatment with Cognitive Behavioral Therapy or Antidepressants
The effect of zotepine, risperidone, clozapine and olanzapine on MK-801-disrupted sensorimotor gating
Effect of Low-Frequency rTMS on Electromagnetic Tomography (LORETA) and Regional Brain Metabolism (PET) in Schizophrenia Patients with Auditory Hallucinations
The findings implicate that the effect is connected with decreased metabolism in the cortex underlying the rTMS site, while facilitation of metabolism is propagated by transcallosal and intrahemispheric connections.