• Publications
  • Influence
Fluoroscopically guided interventional procedures: a review of radiation effects on patients' skin and hair.
Expected skin reactions for an average patient are presented in tabular form as a function of peak skin dose and time after irradiation, and the variability of reactions in different patients is indicated. Expand
The skin: its structure and response to ionizing radiation.
  • J. Hopewell
  • Biology, Medicine
  • International journal of radiation biology
  • 1990
The structural organization of human skin is described and compared with that of the pig, with which it shows many similarities, in order that the response of the skin to ionizing radiation may be more fully understood. Expand
Time- and dose-related changes in the white matter of the rat brain after single doses of X rays.
In the latent period prior to the onset of necrosis of the fimbria, a number of dose-related changes were seen in the vasculature and the associated astroglial cells that appeared to represent a "unit of tissue injury" and apparently increased with time after irradiation until necrosis ensued. Expand
Radiation as a risk factor for cardiovascular disease.
The evidence presented suggests an association between cardiovascular disease and exposure to low-to-moderate levels of radiation, as well as the well-known association at high doses. Expand
The influence of field size on the late tolerance of the rat spinal cord to single doses of X rays.
Dose-related changes in the latency for the development of paralysis, or for the presence of histological lesions in the spinal cord, indicated a dependency on the length of spine irradiated, and the importance of field size was indicated. Expand
Preclinical evaluation of the cardiotoxicity of PK2: A novel HPMA copolymer–doxorubicin–galactosamine conjugate antitumour agent
In this study, PK2 displayed a ∼5-fold reduction in cardiotoxicity relative to free DOX and this supported the progression of PK2 into early clinical investigation. Expand
Radiation-therapy effects on bone density.
  • J. Hopewell
  • Medicine
  • Medical and pediatric oncology
  • 1 September 2003
Pathological observed in patient tissues, indicates a clear role for vascular changes in the development of osteopenia, although there remains some uncertainty as to the effects of osteoblast cell loss. Expand
Response of rat skin to boron neutron capture therapy with p-boronophenylalanine or borocaptate sodium.
It was concluded on the basis of these calculations that the microdistribution of the two neutron capture agents had a critical bearing on the overall biological effect after thermal neutron activation. Expand
The radiobiological principles of boron neutron capture therapy: a critical review.
The radiobiology of the dose components in a BNCT exposure is examined. The effect of exposure time in determining the biological effectiveness of γ-rays, due to the repair of sublethal damage, hasExpand
Response of the central nervous system to boron neutron capture irradiation: evaluation using rat spinal cord model.
The response of the central nervous system to boron neutron capture irradiation, with either p-boronophenylalanine (BPA) or borocaptate sodium (BSH) as neutron capture agents, has been assessed usingExpand