Skip to search formSkip to main contentSkip to account menu
Naloxone protects rat dopaminergic neurons against inflammatory damage through inhibition of microglia activation and superoxide generation.
TLDR
Results suggest that naloxone at least in part interferes with the binding of LPS to cell membranes to inhibit microglia activation and protect dopaminergic neurons as well as other neurons in the midbrain cultures from inflammatory damage.
View on PubMed
Systemic infusion of naloxone reduces degeneration of rat substantia nigral dopaminergic neurons induced by intranigral injection of lipopolysaccharide.
  • B. Liu, J. Jiang, J. Hong
  • Biology, Psychology
    The Journal of pharmacology and experimental…
  • 1 October 2000
TLDR
In vivo results and cell culture observations confirmed that naloxone protects dopaminergic neurons against inflammation-mediated degeneration through inhibition of microglial activation and suggest that n aloxone would have therapeutic efficacy in the treatment of inflammation-related neurological disorders.
View on PubMed
Increase of neurotensin content elicited by neuroleptics in nucleus accumbens.
TLDR
The increase of neurotensin-IR content caused by haloperidol chloropromazine, trifluoroperazine and pimozide in accumbens and striatum suggests a modulation of neurotENSin metabolism, synthesis or utilization directly or indirectly through dopaminergic synapses.
View on PubMed
Systemic administration of kainic acid differentially regulates the levels of prodynorphin and proenkephalin mRNA and peptides in the rat hippocampus.
View on PubMed
Coordinate and differential regulation of phenylethanolamine N-methyltransferase, tyrosine hydroxylase and proenkephalin mRNAs by neural and hormonal mechanisms in cultured bovine adrenal medullary…
View on Elsevier
The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and proinflammatory cytokines in mixed glial cell cultures.
TLDR
The results demonstrate that the production of NO, TNF-alpha, IL-1, or IL-6 from glial cells is differentially regulated by HIV-1IIIB gp120 and HIV- 1SF2 gp120, and that the transcriptional regulation is involved in the gp120-induced IL- 6 production.
View on PubMed
Role of microglia in inflammation-mediated degeneration of dopaminergic neurons: neuroprotective effect of interleukin 10.
TLDR
IL-10, an immunosuppressive cytokine, reduced the inflammation-mediated degeneration of dopaminergic neurons through the inhibition of microglial activation in rats and significantly attenuated the lipopolysaccharide induced DA neuronal degeneration.
View on PubMed
Determination of methionine enkephalin in discrete regions of rat brain
View on Elsevier
Implications of prolonged expression of Fos-related antigens.
View on PubMed
Relationship between hippocampal opioid peptides and seizures
View on Elsevier
...
...
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy, Terms of Service, and Dataset License