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The covalent binding of [14C]acetaminophen to mouse hepatic microsomal proteins: the specific binding to calreticulin and the two forms of the thiol:protein disulfide oxidoreductases.
The data might suggest that acetaminophen hepatotoxicity results from the formation of the reactive metabolite within the endoplasmic reticulum within the centre of mouse hepatic microsomes and blocks the posttranslational modification of secretory and membrane proteins.
Population-based case–control study of AhR (aryl hydrocarbon receptor) and CYP1A2 polymorphisms and breast cancer risk
The results from this study suggest that the AhR Lys554Arg polymorphism may be a genetic susceptibility factor for breast cancer, whereas CYP1A2*1F, which is a potentially functional single nucleotide polymorphism, may not be related to breast cancer risk.
The effect of aging on the chaperone concentrations in the hepatic, endoplasmic reticulum of male rats: the possible role of protein misfolding due to the loss of chaperones in the decline in…
- R. R. Erickson, Lisa M Dunning, J. Holtzman
- BiologyThe journals of gerontology. Series A, Biological…
- 1 May 2006
Considering the role of the ER chaperones in membrane and secretory protein posttranslational processing, these data support the concept that their loss could lead to many of the physiological declines associated with aging.
The role of catalytic superoxide formation in the O2 inhibition of nitroreductase.
The mechanism of microsomal and mitochondrial nitroreductase. Electron spin resonance evidence for nitroaromatic free radical intermediates.
It is suggested that the formation of nitroaromatic anion radicals is mediated through a flavine and not cytochrome P-450, which is proposed to account for the well-known O2 inhibition of microsomal nitroreductase.
Low Serum Glutathione Peroxidase Activity Is Associated with Increased Cardiovascular Mortality in Individuals with Low HDLc’s
Individuals with both low HDLc and GPx3 activity are at markedly increased risk for death from CVD.
The pharmacokinetics of daunomycin in man
- D. Alberts, N. R. Bachur, J. Holtzman
- Medicine, BiologyClinical pharmacology and therapeutics
- 1 January 1971
The plasma levels, urinary excretion, and tissue levels of daunomycin and its fluorescent metabolites were determined in patients treated with this drug for disseminated solid malignancies and it is proposed that the current treatment schedule be revised to a single intravenous dose.
In cerebrospinal fluid ER chaperones ERp57 and calreticulin bind β-amyloid
The role of covalent binding to microsomal proteins in the hepatotoxicity of acetaminophen.
- J. Holtzman
- BiologyDrug metabolism reviews