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Identification of a family of animal sphingomyelin synthases
Sphingomyelin (SM) is a major component of animal plasma membranes. Its production involves the transfer of phosphocholine from phosphatidylcholine onto ceramide, yielding diacylglycerol as a sideExpand
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Drs2p-related P-type ATPases Dnf1p and Dnf2p are required for phospholipid translocation across the yeast plasma membrane and serve a role in endocytosis.
Plasma membranes in eukaryotic cells display asymmetric lipid distributions with aminophospholipids concentrated in the inner and sphingolipids in the outer leaflet. This asymmetry is maintained byExpand
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Lipid traffic: floppy drives and a superhighway
Understanding how membrane lipids achieve their non-random distribution in cells is a key challenge in cell biology at present. In addition to being sorted into vesicles that can cross distances ofExpand
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The Multigenic Sphingomyelin Synthase Family*
Sphingomyelin (SM)3 is a vital component of cellular membranes in organisms ranging from mammals to protozoa. Its production involves the enzymatic transfer of a phosphocholine head groupExpand
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Cdc50p Plays a Vital Role in the ATPase Reaction Cycle of the Putative Aminophospholipid Transporter Drs2p*♦
Members of the P4 subfamily of P-type ATPases are believed to catalyze transport of phospholipids across cellular bilayers. However, most P-type ATPases pump small cations or metal ions, and atomicExpand
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CDC50 Proteins Are Critical Components of the Human Class-1 P4-ATPase Transport Machinery*
Members of the P4 subfamily of P-type ATPases catalyze phospholipid transport and create membrane lipid asymmetry in late secretory and endocytic compartments. P-type ATPases usually pump smallExpand
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Tracking down lipid flippases and their biological functions
The various organellar membranes of eukaryotic cells display striking differences in the composition, leaflet distribution and transbilayer movement of their lipids. In membranes such as theExpand
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Loss of P4 ATPases Drs2p and Dnf3p disrupts aminophospholipid transport and asymmetry in yeast post-Golgi secretory vesicles.
Eukaryotic plasma membranes generally display asymmetric lipid distributions with the aminophospholipids concentrated in the cytosolic leaflet. This arrangement is maintained by aminophospholipidExpand
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Both Sphingomyelin Synthases SMS1 and SMS2 Are Required for Sphingomyelin Homeostasis and Growth in Human HeLa Cells*
Sphingomyelin (SM) is a vital component of cellular membranes in organisms ranging from mammals to protozoa. Its production involves the transfer of phosphocholine from phosphatidylcholine toExpand
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Phosphatidylserine Stimulation of Drs2p·Cdc50p Lipid Translocase Dephosphorylation Is Controlled by Phosphatidylinositol-4-phosphate*
Background: Transport of phosphatidylserine (PS) analogs by the Drs2p flippase is regulated by PtdIns(4)P. Results: PS stimulates dephosphorylation of the Drs2p·Cdc50p complex only in the presence ofExpand
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