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Generation of T-cell receptor retrogenic mice
TLDR
This protocol describes a new method for expressing defined T CR-α and TCR-β proteins from a single 2A peptide–linked multicistronic retroviral vector in mice, using retrovirus-mediated stem cell gene transfer. Expand
Orchestrated Intron Retention Regulates Normal Granulocyte Differentiation
TLDR
Bioinformatic analyses of transcriptomic and proteomic data of normal white blood cell differentiation reveal IR as a physiological mechanism of gene expression control and establish that IR coupled with NMD is a conserved mechanism in normal granulopoiesis. Expand
Substrate elasticity provides mechanical signals for the expansion of hemopoietic stem and progenitor cells
TLDR
The data suggest that substrate elasticity and tensegrity are important mechanisms influencing hemopoietic stem and progenitor cell subsets and could be exploited to facilitate cell culture. Expand
Distinct Immune Cell Populations Define Response to Anti-PD-1 Monotherapy and Anti-PD-1/Anti-CTLA-4 Combined Therapy.
TLDR
An EOMES+CD69+CD45RO+ effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared with non-responders was associated with longer progression-free survival in patients treated with single agent and greater tumor shrinkage in both treatments. Expand
Androgen receptor and nutrient signaling pathways coordinate the demand for increased amino acid transport during prostate cancer progression.
TLDR
The results show how prostate cancer cells respond to demands for increased essential amino acids by coordinately activating amino acid transporter pathways vital for tumor outgrowth. Expand
General Nature of the STAT3-Activated Anti-Inflammatory Response1
TLDR
The AIR is a generic cytokine signaling pathway dependent on STAT3 but not unique to the IL-10R, and is not related to the innate immune response. Expand
ASCT2/SLC1A5 controls glutamine uptake and tumour growth in triple-negative basal-like breast cancer
TLDR
Preclinical evidence for the feasibility of novel therapies exploiting ASCT2 transporter activity in breast cancer is provided, particularly in the high-risk basal-like subgroup of TN breast cancer where there is not only high expression of AsCT2, but also a marked reliance on its activity for sustained cellular proliferation. Expand
Targeting amino acid transport in metastatic castration-resistant prostate cancer: effects on cell cycle, cell growth, and tumor development.
TLDR
Inhibition of LAT transporters may provide a novel therapeutic target in metastatic castration-resistant prostate cancer, via suppression of mammalian target of rapamycin complex 1 activity and M-phase cell cycle genes. Expand
Rapid analysis of T-cell selection in vivo using T cell–receptor retrogenic mice
TLDR
A methodology for the rapid expression of TCRs in mice using 2A peptide–linked multicistronic retroviral vectors to transduce stem cells of any background before adoptive transfer into RAG-1−/− mice is provided. Expand
Rapid analysis of T-cell selection in vivo using T cell–receptor retrogenic mice
Although T-cell receptor (TCR) transgenic as well as knockout and knockin mice have had a large impact on our understanding of T-cell development, signal transduction and function, the need to crossExpand
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