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Consensus Nomenclature for in vivo Imaging of Reversibly Binding Radioligands
An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands.
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Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease.
Lentiviral delivery of glial cell line-derived neurotrophic factor (lenti-GDNF) was tested for its trophic effects upon degenerating nigrostriatal neurons in nonhuman primate models of Parkinson'sExpand
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In vivo positron emission tomographic evidence for compensatory changes in presynaptic dopaminergic nerve terminals in Parkinson's disease
Clinical symptoms of Parkinson's disease (PD) do not manifest until dopamine (DA) neuronal loss reaches a symptomatic threshold. To explore the mechanisms of functional compensation that occur inExpand
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Neurotoxicity of Glucocorticoids in the Primate Brain
Severe and prolonged physical and psychological stress is known to cause brain damage; long-term torture victims in prison have later developed psychiatric disorders and cerebral cortical atrophyExpand
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Age‐dependent decline of dopamine D1 receptors in human brain: A PET study
Radioligand binding studies in animals have demonstrated age‐related loss of dopamine receptors in the caudate and putamen. In humans, while age‐related declines in dopamine D2 receptors have beenExpand
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Metabolic rate in the right amygdala predicts negative affect in depressed patients
THE role of the amygdala in major depression was investigated. Resting regional cerebral metabolic rate (rCMRglu) was measured with [18 F]fluorodeoxyglucose positron emission tomography (PET) in twoExpand
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Age‐related declines in nigral neuronal function correlate with motor impairments in rhesus monkeys
Although the role of dopamine dysfunction is well established in Parkinson's disease, the effect of nigrostriatal degeneration on motor performance during normal aging is less well understood. InExpand
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Increase in Dopamine Turnover Occurs Early in Parkinson's Disease: Evidence from a New Modeling Approach to PET 18F-Fluorodopa Data
An increase in dopamine turnover has been hypothesized to occur early in Parkinson's disease (PD) as a compensatory mechanism for dopaminergic neuronal loss. A new approach to the determination ofExpand
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A Reversible Tracer Analysis Approach to the Study of Effective Dopamine Turnover
Changes in dopamine turnover resulting from disease states such as Parkinson's disease may be reflected in corresponding changes in the kinetics of the positron emission tomographic tracerExpand
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Evaluation of Dopaminergic Presynaptic Integrity: 6-[18F]Fluoro-L-Dopa Versus 6-[18F]Fluoro-L-m-Tyrosine
The effectiveness of 6-[18F]fluoro-L-m-tyrosine (6FMT) to evaluate dopamine presynaptic integrity was compared to that of 6-[18F]fluoro-L-dopa (6FDOPA) in vivo by positron emission tomography (PET).Expand
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