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A gene atlas of the mouse and human protein-encoding transcriptomes.
The tissue-specific pattern of mRNA expression can indicate important clues about gene function. High-density oligonucleotide arrays offer the opportunity to examine patterns of gene expression on a
Orchestrated transcription of key pathways in Arabidopsis by the circadian clock.
TLDR
This study presents a comprehensive view of the temporal compartmentalization of physiological pathways by the circadian clock in a eukaryote.
Mop3 Is an Essential Component of the Master Circadian Pacemaker in Mammals
TLDR
Analysis of Period gene expression in the suprachiasmatic nucleus (SCN) indicates that these behavioral phenotypes arise from loss of circadian function at the molecular level, and provides genetic evidence that MOP3 is the bona fide heterodimeric partner of mCLOCK.
Large-scale analysis of the human and mouse transcriptomes
TLDR
This work generated and analyzed gene expression from 91 human and mouse samples across a diverse array of tissues, organs, and cell lines to reveal insights into molecular and physiological gene function, mechanisms of transcriptional regulation, disease etiology, and comparative genomics.
JTK_CYCLE: An Efficient Nonparametric Algorithm for Detecting Rhythmic Components in Genome-Scale Data Sets
TLDR
JTK_CYCLE’s improved power led to the identification of a novel cluster of RNA-interacting genes whose abundance is under clear circadian regulation and is an ideal tool for identifying and characterizing oscillations in genome-scale data sets.
Coordinated Transcription of Key Pathways in the Mouse by the Circadian Clock
TLDR
Genetic and genomic analysis suggests that a relatively small number of output genes are directly regulated by core oscillator components, and major processes regulated by the SCN and liver were found to be under circadian regulation.
Genome-wide analysis of cAMP-response element binding protein occupancy, phosphorylation, and target gene activation in human tissues.
TLDR
The results indicate that CREB phosphorylation alone is not a reliable predictor of target gene activation and that additional CREB regulatory partners are required for recruitment of the transcriptional apparatus to the promoter.
Urocortin II: A member of the corticotropin-releasing factor (CRF) neuropeptide family that is selectively bound by type 2 CRF receptors
TLDR
Cl cloning and initial characterization of a previously unidentified CRF-related neuropeptide, urocortin II (Ucn II), are described, which is expressed centrally and binds selectively toCRF-R2, and identified as a new member of the CRF family of neuropePTides.
A circadian gene expression atlas in mammals: Implications for biology and medicine
TLDR
High-resolution multiorgan expression data is generated showing that nearly half of all genes in the mouse genome oscillate with circadian rhythm somewhere in the body, and the majority of best-selling drugs and World Health Organization essential medicines directly target the products of rhythmic genes.
A Heat-Sensitive TRP Channel Expressed in Keratinocytes
TLDR
The cloning and characterization of a novel thermosensitive TRP channel, TRPV3, which is activated at innocuous (warm) temperatures and shows an increased response at noxious temperatures is described.
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