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Consensus guidelines for the detection of immunogenic cell death
TLDR
Strategies conceived to detect surrogate markers of ICD in vitro and to screen large chemical libraries for putative I CD inducers are outlined, based on a high-content, high-throughput platform that was recently developed. Expand
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
TLDR
It is shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue, indicating that directed radiotherapy can improve the efficacy of tumor immunotherapy. Expand
Sublethal Irradiation of Human Tumor Cells Modulates Phenotype Resulting in Enhanced Killing by Cytotoxic T Lymphocytes
TLDR
The results of this study suggest that nonlethal doses of radiation can be used to make human tumors more amenable to immune system recognition and attack and form the rational basis for the combinatorial use of cancer vaccines and local tumor irradiation. Expand
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Reits et al. 2006. J. Exp. Med. doi:10.1084/jem.20052494 [OpenUrl][1][Abstract/FREE Full Text][2] [1]:Expand
Combining a Recombinant Cancer Vaccine with Standard Definitive Radiotherapy in Patients with Localized Prostate Cancer
TLDR
This vaccine regimen can be safely given in patients undergoing radiation therapy for localized prostate cancer, with the majority of patients generating a PSA-specific cellular immune response to vaccine. Expand
Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death
TLDR
The main molecular, immunological, preclinical, and clinical aspects of ICD are summarized and tabulate in an attempt to capture the essence of this phenomenon, and identify future challenges for this rapidly expanding field of investigation. Expand
Acquisition of CD80 (B7-1) by T Cells
TLDR
It is demonstrated here that naive CD4+ T cells actually acquire the costimulatory molecule CD80 (B7-1) from syngeneic APCs after activation, and for the first time that naive T cells, following acquisition of CD80 from APCs, were themselves shown to be capable of acting as APCs. Expand
An NK cell line (haNK) expressing high levels of granzyme and engineered to express the high affinity CD16 allele
TLDR
The studies reported here show high levels of granzyme in ha NK cells, and demonstrate the effects of irradiation of haNK cells on multiple phenotypic markers, viability, IL-2 production, and lysis of a spectrum of human tumor cells. Expand
Immunologic and prognostic factors associated with overall survival employing a poxviral-based PSA vaccine in metastatic castrate-resistant prostate cancer
TLDR
Evidence is provided that patients with more indolent mCRPC (Halabi predicted survival ≥18 months) may best benefit from vaccine therapy, and treg suppressive function was shown to decrease following vaccine in patients surviving longer than predicted, and increase in patients survive less than predicted. Expand
Irradiation of Tumor Cells Up-Regulates Fas and Enhances CTL Lytic Activity and CTL Adoptive Immunotherapy
TLDR
Results showed for the first time that regulation of the Fas pathway in tumor cells by irradiation plays an important role in their sensitization to Ag-specific CTL; and a combination regimen of tumor-targeted irradiation and CTL promotes more effective antitumor responses in vivo, which may have implications for the combination of immunotherapy and radiation therapy. Expand
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