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A New Insect-Specific Flavivirus from Northern Australia Suppresses Replication of West Nile Virus and Murray Valley Encephalitis Virus in Co-infected Mosquito Cells
It is demonstrated that prior infection of cultured mosquito cells with PCV suppressed subsequent replication of the medically significant West Nile and Murray Valley encephalitis viruses by 10–43 fold, suggesting that superinfection exclusion can occur between ISFs and vertebrate-infecting flaviviruses despite their high level of genetic diversity. Expand
Characterization of Virulent West Nile Virus Kunjin Strain, Australia, 2011
An encephalitis outbreak among horses was caused by a pathogenic variant of Kunjin virus, which spread through the equine immune system through the nervous system and into the brain. Expand
The West Nile Virus-Like Flavivirus Koutango Is Highly Virulent in Mice due to Delayed Viral Clearance and the Induction of a Poor Neutralizing Antibody Response
A West Nile-like virus, Koutango virus (WNVKOU), was identified that was more virulent than a known virulent lineage I virus, WNVNY99, and was associated with poor viral clearance and the induction of a poor neutralizing antibody response. Expand
Commensal Viruses of Mosquitoes: Host Restriction, Transmission, and Interaction with Arboviral Pathogens
It is shown that many ISVs are efficiently transmitted directly from the female mosquito to their progeny via infected eggs, and, moreover, that persistent infection of mosquito cell cultures or whole mosquitoes with ISVs can restrict subsequent infection, replication, and transmission of some mosquito-borne viral pathogens. Expand
Mutation of the N-Terminal Region of Chikungunya Virus Capsid Protein: Implications for Vaccine Design
A previously uncharacterized nucleolar localization sequence (NoLS) in CHIKV capsid protein is identified, a functional analysis of site-directed mutants of the capsidprotein NoLS is begun, and the effect of the NoLS mutation onCHIKV pathogenesis in vivo and its potential to influence CHikV vaccine design are examined. Expand
Discovery of a novel iflavirus sequence in the eastern paralysis tick Ixodes holocyclus
Next-generation sequencing of I. holocyclus salivary glands yielded a full-length genome sequence which phylogenetically groups with viruses classified in the Iflaviridae family and shares 45% amino acid similarity with its closest relative Bole hyalomma asiaticum virus 1. Expand
The insect-specific Palm Creek virus modulates West Nile virus infection in and transmission by Australian mosquitoes
BackgroundInsect-specific viruses do not replicate in vertebrate cells, but persist in mosquito populations and are highly prevalent in nature. These viruses may naturally regulate the transmissionExpand
A New Species of Mesonivirus from the Northern Territory, Australia
The evolutionary distance between CASV and two of its closest relatives, Cavally and Hana viruses, along with its isolation from a different genus of mosquitoes captured on a separate continent indicate that CASV is a new species. Expand
A New Clade of Insect-Specific Flaviviruses from Australian Anopheles Mosquitoes Displays Species-Specific Host Restriction
A genetically divergent group of insect-specific flaviviruses from Anopheles mosquitoes that do not replicate in arthropod cell lines or heterologous Anophele species, exhibiting unprecedented specialization for their host species is reported, representing a significant advance in knowledge of mosquito-borne flavivirus ecology, host restriction, and evolution. Expand
West Nile Virus-Induced Activation of Mammalian Target of Rapamycin Complex 1 Supports Viral Growth and Viral Protein Expression
The requirement for TORC1 function in support of WNV RNA translation is demonstrated and insight into the mechanisms underlying flaviviral RNA translation in mammalian cells is provided. Expand