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Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers
Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in human subjects who chronically smoke cannabis is shown, using positron emission tomography imaging, for the first direct demonstration of cortical cannabinoids CB1 receptor downregulation as a neuroadaptation that may promote cannabis dependence in human brain.
Obesity is associated with white matter atrophy: A combined diffusion tensor imaging and voxel‐based morphometric study
The obesity‐related changes in brain white and gray matter integrity were examined and it was found that obesity influences brain structure through changes in white andgray matter integrity.
Is emotional contagion special? An fMRI study on neural systems for affective and cognitive empathy
C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo
Decreased brain serotonin 5-HT1A receptor availability in medication-naive patients with major depressive disorder: an in-vivo imaging study using PET and [carbonyl-11C]WAY-100635.
- J. Hirvonen, H. Karlsson, J. Hietala
- Biology, PsychologyInternational Journal of Neuropsychopharmacology
- 1 June 2008
A widespread reduction in the availability of serotonin 5-HT1A receptors was demonstrated in a relatively large sample of drug-naive primary-care patients with MDD, suggesting the involvement of this receptor subtype in the pathophysiology of the illness.
Dorsal Striatum and Its Limbic Connectivity Mediate Abnormal Anticipatory Reward Processing in Obesity
Findings suggest that enhanced sensitivity to external food cues in obesity may involve abnormal stimulus-response learning and incentive motivation subserved by the dorsal caudate nucleus, which in turn may be due to abnormally high input from the amygdala and insula and dysfunctional inhibitory control by the frontal cortical regions.
Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein.
Binding of TSPO is increased both ipsilateral and contralateral to seizure foci in patients with TLE, suggesting ongoing inflammation, and anti-inflammatory therapy may play a role in treating drug-resistant epilepsy.
Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand
Obesity Is Associated with Decreased μ-Opioid But Unaltered Dopamine D2 Receptor Availability in the Brain
Obesity appears to have unique neurobiological underpinnings in the reward circuit, whereby it is more similar to opioid addiction than to other addictive disorders, and Behavioral and pharmacological strategies for recovering opioidergic function might thus be critical to curb the obesity epidemic.
Increased In Vivo Expression of an Inflammatory Marker in Temporal Lobe Epilepsy
Increased uptake of radioactivity after injection of 11C-PBR28 ipsilateral to the seizure focus in patients with temporal lobe epilepsy is found, suggesting increased expression of TSPO.