J. Hirtz

Publications38
h-index11
Citations1,539
Highly Influential Citations110
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A functional basis for engineering design: Reconciling and evolving previous efforts
TLDR
We reconcile and integrate two independent research efforts into a significantly evolved functional basis. Expand
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  • 103
  • PDF
Investigation of drug absorption from the gastrointestinal tract of man. III. Metoprolol in the colon.
The colonic absorption of metoprolol was indirectly evaluated by measuring drug appearance in plasma following intravenous, jejunal or colonic infusion in six healthy volunteers. Plasma… Expand
  • 65
  • 2
Evaluation of the gastric absorption and emptying of drugs under various pH conditions using a simple intubation method: application to diclofenac.
Sodium diclofenac (50 mg) together with [14 C]-PEG as a non-absorbable marker were dissolved in 400 ml of water (A), phosphate buffer pH 7.5 (B) or a homogenized meal (C). Each of these was ingested… Expand
  • 22
  • 2
EVOLVING A FUNCTIONAL BASIS FOR ENGINEERING DESIGN
TLDR
In this paper, we reconcile and integrate two independent research efforts into a significantly evolved functional basis. Expand
  • 71
  • 2
  • PDF
The gastrointestinal absorption of drugs in man: a review of current concepts and methods of investigation.
  • J. Hirtz
  • Medicine
  • British journal of clinical pharmacology
  • 1 April 1985
The various mechanisms which have been advanced to explain drug absorption are critically reviewed and the limitations of current theories are discussed. Various techniques for investigating drug… Expand
  • 110
  • 1
Investigation of drug absorption from the gastrointestinal tract of man. I. Metoprolol in the stomach, duodenum and jejunum.
Gastrointestinal (GI) absorption of the beta-adrenoceptor blocker metoprolol was investigated in five healthy subjects by means of an intubation method, employing a triple-lumen tube introduced into… Expand
  • 86
[Use of thermogravimetry in the study of the solvation of organic products of pharmaceutical importance].
  • 3
Investigation of drug absorption from the gastrointestinal tract of man. II. Metoprolol in the jejunum and ileum.
Absorption of metoprolol in jejunum and ileum was investigated in eight healthy subjects using an intestinal perfusion technique below an occlusive balloon. An isotonic saline solution, with or… Expand
  • 50
Investigation of drug absorption from the gastrointestinal tract of man. V. Effect of the beta-adrenoceptor antagonist, metoprolol, on postprandial gastric function.
The role of the adrenergic system in normal gastric function was assessed in five healthy volunteers by measuring gastric secretion and emptying after a mixed meal containing a non-absorbable marker,… Expand
  • 8
Jejunal and ileal absorption of oxprenolol in man: influence of nutrients and digestive secretions on jejunal absorption and systemic availability.
1 Study I evaluated the absorption of oxprenolol in the ileum, compared to jejunum, in healthy volunteers by an intestinal perfusion technique. Around 80 mg of drug were delivered as a saline… Expand
  • 7