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A transgenic rat model of Alzheimer's disease with extracellular Aβ deposition
Deposits appeared similar to those observed in the mouse models and displayed surrounding glial and phosphorylated tau reactivity, suggesting that substantially greater amounts of soluble Abeta are not required in the rat to generate Abeta deposition. Expand
Modulation of Secreted β-Amyloid Precursor Protein and Amyloid β-Peptide in Brain by Cholesterol*
- D. Howland, S. Trusko, +8 authors D. Flood
- Chemistry, Medicine
- The Journal of Biological Chemistry
- 26 June 1998
It is demonstrated that secreted APP processing derivatives and Aβ can be modulated in the brain of an animal by diet and evidence that cholesterol plays a role in the modulation of APP processing in vivo is provided. Expand
Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions.
- D. Flood, A. Reaume, +5 authors R. Scott
- Biology, Medicine
- The American journal of pathology
- 1 August 1999
Investigation of the role of oxidative damage in neurodegenerative disease in mice lacking cytoplasmic Cu/Zn superoxide dismutase found it necessary for the maintenance of normal neuromuscular junctions by hindlimb motor neurons to rescued motor neurons from the neuropathy. Expand
Laminar Distribution of Putative Neurotransmitter Amino Acids and Ligand Binding Sites in the Dog Olfactory Bulb
The laminar distribution of ten amino acids, the dipeptide carnosine and nine [3H]ligand binding sites in these layers was determined and Carnosine binding was maximal in the glomerular layer. Expand
Mitochondrial benzodiazepine receptors mediate inhibition of mitochondrial respiratory control.
The results suggest that ligand binding to mitochondrial benzodiazepine receptors results in inhibition of mitochondrial respiratory control, which may help to explain the pleiotropic effects of receptor ligands on intact cells. Expand
Characterization of ligand binding to mitochondrial benzodiazepine receptors.
Evaluated binding sites for peripheral-type or mitochondrial benzodiazepine receptors in intact and fragmented rat kidney mitochondria revealed several new classes of MBR ligands and suggest that the relationship between ligand structure and binding affinity is highly complex. Expand
Cell suspensions from rat olfactory neuroepithelium: Biochemical and histochemical characterization
The ease with which cell suspensions may be produced from the olfactory epithelium is demonstrated, and the importance of utilizing both biochemical and histochemical approaches in studies of mixed populations of cells is emphasized, particularly when the purity of the cell fractions is a consideration. Expand
β-Carboline-3-carboxylic acid ethyl ester antagonizes diazepam activity
The pharmacological data indicate that βCEE has activity that is opposite to, rather than similar to, that of diazepam, and this is in contrast to previous reports on β-carboline-3-carboxylic acid analogues. Expand
Heterogeneity of brain benzodiazepine receptors demonstrated by [3H]propyl beta-carboline-3-carboxylate binding.
The neurochemical sequelae of olfactory bulbectomy.
- J. Hirsch
- Biology, Medicine
- Life sciences
- 12 May 1980
This review summarizes the research over the last 10 years on the neurochemical consequences of olfactory bulbectomy involving catecholamines, indolamine, acetylcholine, amino acid and several putative neurotransmitter systems and proposes additional experiments designed to expand the knowledge of o aroma bulb-brain neurochemical relationships. Expand