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Captopril reduces collagen and mast cell accumulation in irradiated rat lung.
TLDR
These data are the first to demonstrate that the ACE inhibitor captopril might provide a novel intervention in the pathogenesis of radiation fibrosis. Expand
Radiation pneumotoxicity in rats: modification by inhibitors of angiotensin converting enzyme.
TLDR
A novel application for ACE inhibitors in general, and for Captopril in particular, as modifiers of radiation pneumotoxicity are suggested. Expand
The effect of Captopril on benign and malignant reactions in irradiated rat skin.
TLDR
Captopril, known to ameliorate acute lung damage in irradiated rats, also reduces chronic benign and malignant skin reactions in the radiation treatment field. Expand
The genetic basis of strain-dependent differences in the early phase of radiation injury in mouse lung.
TLDR
The phenotype in which fibrosis is found is controlled by autosomal recessive determinants, and strains prone to radiation-induced pulmonary fibrosis and hyaline membranes exhibited intrinsically lower activities of lung plasminogen activator and angiotensin converting enzyme than either the nonfibrosing strains or the nonmagnifying hybrid crosses. Expand
Pentoxifylline does not spare acute radiation reactions in rat lung and skin.
TLDR
The data indicate that pentoxifylline, despite some promising pharmacological actions, has no beneficial effect on acute radiation reactions in rat lung and skin. Expand
Radiation-induced pulmonary endothelial dysfunction and hydroxyproline accumulation in four strains of mice.
TLDR
Strips prone to radiation-induced pulmonary fibrosis exhibit only half as much lung ACE and PLA activity as do strains resistant to fibrosis (CBA and C3H). Expand
Monocrotaline-induced cardiopulmonary injury in rats. Modification by the neutrophil elastase inhibitor SC39026.
TLDR
The data suggest that inappropriate neutrophil elastase activity contributes to monocrotaline pulmonary vasculopathy and hypertension. Expand
Prostacyclin and Thromboxane Production by Irradiated Rat Lung
The production of prostacyclin (PGI2) and thromboxane (TXA2) by irradiated rat lung and the concentration of these prostanoids in the bronchoalveolar lavage (BAL) fluid were measured in ratsExpand
Serum copper concentration as an index of lung injury in rats exposed to hemithorax irradiation.
TLDR
Serum copper concentration is an accurate and minimally invasive index of lung injury in rats irradiated to the hemithorax and can predict lung hydroxyproline (collagen) content in individual irradiated rats. Expand
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