J. Hill

Publications27
h-index18
Citations1,841
Highly Influential Citations75
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Pharmacokinetics of methamphetamine self-administered to human subjects by smoking S-(+)-methamphetamine hydrochloride.
TLDR
A model involving both a fast and a slow input function fit the data from 4 of the 6 subjects and indicated a terminal elimination rate that agreed with results from model-independent pharmacokinetic calculations.
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Cocaine disposition in humans after intravenous injection, nasal insufflation (snorting), or smoking.
TLDR
Metabolism, followed by urinary excretion of metabolites, proved to be the major route of elimination in all cases and hydrolytic products (benzoylecgonine, ecgonine methyl ester) were the major excretion products.
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Biotransformation products of 3,4,4'-trichlorocarbanilide in rat, monkey, and man.
  • C. Birch, R. Hiles, M. Wall
  • Biology, Chemistry
    Drug metabolism and disposition: the biological…
  • 1 March 1978
TLDR
Radioactive materials in the plasma and urine of all three species and in the bile of rats and monkeys were separated by high performance liquid chromatography and showed great similarity between the monkey and the human.
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Effects of contraction and lactic acid on the discharge of group III muscle afferents in cats.
TLDR
In barbiturate-anesthetized cats, afferents whose receptive fields were located in the triceps surae muscles were studied and noted a restored sensitivity to lactic acid during contraction, while in separate experiments DCA lowered arterial and venous lactate concentrations at rest and during contraction.
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Pharmacokinetics of oral methamphetamine and effects of repeated daily dosing in humans.
TLDR
Development of pharmacodynamic tolerance to methamphetamine could not be explained on the grounds of a change in pharmacokinetics, and a one-compartment pharmacokinetic model incorporating a lag time fits the data best.
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Clinical effects of daily methamphetamine administration.
TLDR
The findings indicate that the disposition of methamphetamine and its subjective effects were not altered by this period of daily exposure to a low dose of the drug, and tolerance to the heart-rate accelerating effect was observed.
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Responses of group III and IV muscle afferents to dynamic exercise.
TLDR
Low levels of dynamic exercise stimulate group III and IV muscle afferents, an effect induced by an alpha-motoneuron discharge pattern and recruitment order almost identical to that occurring during dynamic exercise.
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Clinical effects of methamphetamine vapor inhalation.
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Cyclooxygenase blockade attenuates responses of group IV muscle afferents to static contraction.
TLDR
The data suggest that cyclooxygenase metabolites of arachidonic acid are needed for the full expression of the responses of group IV muscle afferents to static contraction.
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Responses of group III and IV muscle afferents to distension of the peripheral vascular bed.
TLDR
It is observed that most of the group IV afferents that were excited by dynamic contractions of the triceps surae muscles also responded either to venous distension or to vasodilatory agents, consistent with the histological findings that a large number of group IV endings have their receptive fields close to the venules and suggest that they can be stimulated by the deformation of these vascular structures when peripheral conductance increases.
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