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The molecular pathology of lecithin:cholesterol acyltransferase (LCAT) deficiency syndromes.
TLDR
This review describes 36 natural mutations in the LCAT gene that result in either familial LCAT deficiency (FLD) or the milder phenotype known as fish-eye disease (FED) and proposes a new classification of the natural mutations that are described to date.
Chloromethyl-X-rosamine (MitoTracker Red) photosensitises mitochondria and induces apoptosis in intact human cells.
TLDR
Chloromethyl-X-rosamine (MitoTracker Red), a mitochondrion-selective fluorescent probe, has a strong photosensitising action that may provide versatile new applications in studies of mitochondrial roles in cell death.
Genetic and environmental factors affecting the incidence of coronary artery disease in heterozygous familial hypercholesterolemia.
TLDR
Those factors, which, in addition to total cholesterol levels, are associated with the development of premature coronary atherosclerosis in heterozygous FH are identified.
A history of photodynamic therapy.
  • M. Daniell, J. Hill
  • Medicine
    The Australian and New Zealand journal of surgery
  • 1 May 1991
TLDR
The discovery of the tumour-localizing ability of haematoporphyrin, together with its phototoxic effect on tumour cells led to the development of photodynamic therapy, a promising tool in modern cancer treatment.
Two novel molecular defects in the LCAT gene are associated with fish eye disease.
TLDR
It is concluded that the LCATR135D mutation is causative for complete LCAT deficiency and that the clinical phenotype of fish eye disease seen in this patient is due to the Pro10 mutation.
Chloride intracellular channels modulate acute ethanol behaviors in Drosophila, Caenorhabditis elegans and mice
TLDR
A novel, conserved role for chloride intracellular channels (CLICs) in alcohol‐related behavior is established and key roles for Clic genes in behavioral responses to acute alcohol in Drosophila, C. elegans and mice are demonstrated.
Lecithin:cholesterol acyltransferase: role of N-linked glycosylation in enzyme function.
TLDR
It is demonstrated that all four potential N-glycosylation sites in LCAT are used and the presence of carbohydrate at each site has diverse effects on the enzyme activity.
Photodynamic therapy: a 5-year study of its effectiveness in the treatment of posterior uveal melanoma, and evaluation of haematoporphyrin uptake and photocytotoxicity of melanoma cells in tissue
A human melanoma cell line RVH-421 which selectively demonstrates melanin synthesis when cultured in L15 Leibowitz medium but not in RPMI medium was used as a model to examine haematoporphyrin
Subdomain Chimeras of Hepatic Lipase and Lipoprotein Lipase
TLDR
Substitution of LPL sequences into the HL carboxyl-terminal domain resulted in the production of functional lipases, but with distinct heparin binding properties, as well as indicating that apoC-II also interacted with the last half of the carboxymal domain to achieve maximal lipolytic activation.
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