J. Hietala

Publications251
h-index55
Citations10,210
Highly Influential Citations387
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The A1 allele of the human D2 dopamine receptor gene predicts low D2 receptor availability in healthy volunteers
Positron emission tomography (PET) studies have revealed significant interindividual variation in dopamine D2 receptor density in vivo in human striatum.1 Low D2 receptor binding in vivo has been… Expand
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Sex differences in the striatal dopamine D2 receptor binding characteristics in vivo.
OBJECTIVE The authors investigated whether striatal dopamine D2 receptor binding characteristics in vivo are similar in men and women and whether there are sex-related differences in the decline in… Expand
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C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
C957T polymorphism of the dopamine D2 receptor (DRD2) gene affects striatal DRD2 availability in vivo
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Association between low activity serotonin transporter promoter genotype and early onset alcoholism with habitual impulsive violent behavior
A common 44-base pair insertion/deletion polymorphism in the promoter region of the human serotonin transporter (5-HTT) gene has been observed to be associated with affective illness and… Expand
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Age-related dopamine D2/D3 receptor loss in extrastriatal regions of the human brain
Loss of dopamine D2-like receptors in the striatum has been associated with both normal human aging and impairment of cognitive and motor functions in the elderly. To investigate whether there are… Expand
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Comparison of the Transient Equilibrium and Continuous Infusion Method for Quantitative PET Analysis of [11C]Raclopride Binding
Several approaches have been applied for quantification of D2 dopamine receptors in positron emission tomography studies using [11C]raclopride. Initial approaches were based on analyses of data… Expand
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Mesolimbic dopamine release is linked to symptom severity in pathological gambling
TLDR
We studied striatal dopamine release during gambling with an ecologically valid slot machine gambling task in pathological gamblers. Expand
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C957T polymorphism of the human dopamine D2 receptor gene predicts extrastriatal dopamine receptor availability in vivo
The C957T (rs6277) single nucleotide polymorphism (SNP) of the human dopamine D2 receptor (DRD2) gene (DRD2) affects DRD2 mRNA stability and has been shown to predict striatal DRD2 availability… Expand
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Depressive symptoms and presynaptic dopamine function in neuroleptic-naive schizophrenia
We have previously reported aberrations in the striatal presynaptic dopamine function in neuroleptic-naive schizophrenic patients compared to healthy controls (Hietala, J., Syvälahti, E., Vuorio, K.… Expand
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Association between the functional variant of the catechol-O-methyltransferase (COMT) gene and type 1 alcoholism
Catechol-O-methyltransferase (COMT) is an enzyme which has a crucial role in the metabolism of dopamine. It has been suggested that a common functional genetic polymorphism in the COMT gene, which… Expand
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