J. Heuser

Publications300
h-index109
Citations44,565
Highly Influential Citations1,883
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Molecular Anatomy of a Trafficking Organelle
TLDR
A model has been constructed that integrates all quantitative data and includes structural models of abundant proteins and, with the exception of the V-ATPase, contains numerous copies of proteins essential for membrane traffic and neurotransmitter uptake.
EVIDENCE FOR RECYCLING OF SYNAPTIC VESICLE MEMBRANE DURING TRANSMITTER RELEASE AT THE FROG NEUROMUSCULAR JUNCTION
TLDR
During stimulation the intracellular compartments of this synapse change shape and take up extracellular protein in a manner which indicates that synaptic vesicle membrane added to the surface during exocytosis is retrieved by coated vesicles and recycled into new synaptic vESicles by way of intermediate cisternae.
Caveolin, a protein component of caveolae membrane coats
TLDR
Structural analysis of the striated coat of caveolae reveals a third type of coated membrane specialization that is involved in molecular transport and is named caveolin, suggesting that this molecule is a component of the coat.
Lack of acidification in Mycobacterium phagosomes produced by exclusion of the vesicular proton-ATPase.
TLDR
Immunoelectron microscopy of infected macrophages and immunoblotting of isolated phagosomes showed that Mycobacterium vacuoles acquire the lysosomal membrane protein LAMP-1, but not the vesicular proton-adenosine triphosphatase (ATPase) responsible for phagosomal acidification.
Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections
TLDR
It is discovered that the intracellular bacteria matured into biofilms, creating pod-like bulges on the bladder surface, which explains how bladder infections can persist in the face of robust host defenses.
Role of Escherichia coli Curli Operons in Directing Amyloid Fiber Formation
TLDR
Biochemical, biophysical, and imaging analyses revealed that fibers produced by Escherichia coli called curli were amyloid, and curli biogenesis was dependent on the nucleation-precipitation machinery requiring the CsgE and CsgF chaperone-like and nucleator proteins, respectively.
Structure and Conformational Changes in NSF and Its Membrane Receptor Complexes Visualized by Quick-Freeze/Deep-Etch Electron Microscopy
TLDR
Together, these images suggest how NSF could dissociate the SNARE complex and how association and dissociation of the complex could be related to membrane fusion.
Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation
TLDR
In spite of their seeming unrelatedness, both K+ depletion and hypertonic treatment cause coated pits to disappear, and both induce abnormal clathrin polymerization into empty microcages, which suggests that in both cases, an abnormal formation of microc cages inhibits endocytosis.
Drosophila Spire is an actin nucleation factor
TLDR
Drosophila protein Spire represents a third class of actin nucleation factor that nucleates new filaments at a rate similar to that of the formin family of proteins but slower than in the activated Arp2/3 complex, and it remains associated with the slow-growing pointed end of the new filament.
Synaptic vesicle exocytosis captured by quick freezing and correlated with quantal transmitter release
TLDR
The utility of quick- freezing as a technique to capture biological processes as evanescent as synaptic transmission as well as physiological demonstrations that quanta are discharged independently has been established.
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