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Bioavailability of pure isoflavones in healthy humans and analysis of commercial soy isoflavone supplements.
Differences in the pharmacokinetics of isoflavone glycosides compared with their respective beta-glycosides are demonstrated and indicate a need for improvement in quality assurance and standardization of such products.
Exposure of infants to phyto-oestrogens from soy-based infant formula
Bioavailability, disposition, and dose-response effects of soy isoflavones when consumed by healthy women at physiologically typical dietary intakes.
There were no differences in the pharmacokinetics of daidzein and genistein between pre- and postmenopausal women, indicating absorption and disposition of isoflavones to be independent of age or menopausal status.
Isoflavone content of infant formulas and the metabolic fate of these phytoestrogens in early life.
- K. Setchell, L. Zimmer‐Nechemias, J. Cai, J. Heubi
- Chemistry, MedicineAmerican Journal of Clinical Nutrition
- 1 December 1998
The high steady state plasma concentration of isoflavones in infants fed soy-based formula is explained by reduced intestinal biotransformation, as evidenced by low or undetectable concentrations of equol and other metabolites, and is maintained by constant daily exposure from frequent feeding.
S-equol, a potent ligand for estrogen receptor beta, is the exclusive enantiomeric form of the soy isoflavone metabolite produced by human intestinal bacterial flora.
Humans have acquired an ability to exclusively synthesize S-equol from the precursor soy isoflavone daidzein, and it is significant that this enantiomer has a relatively high affinity for estrogen receptor beta.
Evidence for lack of absorption of soy isoflavone glycosides in humans, supporting the crucial role of intestinal metabolism for bioavailability.
- K. Setchell, N. Brown, J. Heubi
- Chemistry, BiologyAmerican Journal of Clinical Nutrition
- 1 August 2002
Isoflavone glycosides are not absorbed intact across the enterocyte of healthy adults, and their bioavailability requires initial hydrolysis of the sugar moiety by intestinal beta-glucosidases for uptake to the peripheral circulation.
Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2).
- P. Oelkers, L. Kirby, J. Heubi, P. Dawson
- Biology, MedicineJournal of Clinical Investigation
- 15 April 1997
It is established that SLC10A2 mutations can cause primary bile acid malabsorption and underscore the ileal Na+/bile acid cotransporter's role in intestinal reclamation of bile acids.
NASPGHAN guidelines for training in pediatric gastroenterology.
E.G.A.C.R. has served on th served on the board o and Enteral Nutrition; her institution has rec collaborative and Prov pensation from Child L.G., and J.T. has rec Pediatrics, Prometheu conflicts of interest.
Cutaneous Crohn's disease in children.
Pharmacokinetics, tolerability, and clinical effectiveness of quetiapine fumarate: an open-label trial in adolescents with psychotic disorders.
- B. Mcconville, L. Arvanitis, J. Heubi
- Medicine, PsychologyThe Journal of clinical psychiatry
- 1 April 2000
Quetiapine pharmacokinetics were dose proportional in adolescents and were similar to those previously reported for adults, well tolerated and effective in the small number of adolescents studied.