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Phenotypic and molecular characterization of the claudin-low intrinsic subtype of breast cancer
TLDR
It is confirmed that a prognostically relevant differentiation hierarchy exists across all breast cancers in which the claudin-low subtype most closely resembles the mammary epithelial stem cell. Expand
Identification of conserved gene expression features between murine mammary carcinoma models and human breast tumors
TLDR
Although no single mouse model recapitulated all the expression features of a given human subtype, these shared expression features provide a common framework for an improved integration of murine mammary tumor models with human breast tumors. Expand
Residual breast cancers after conventional therapy display mesenchymal as well as tumor-initiating features
TLDR
Supporting evidence is provided that the residual breast tumor cell populations surviving after conventional treatment may be enriched for subpopulations of cells with both tumor-initiating and mesenchymal features. Expand
Core epithelial-to-mesenchymal transition interactome gene-expression signature is associated with claudin-low and metaplastic breast cancer subtypes
TLDR
The EMT core signature associates closely with the claudin-low and metaplastic breast cancer subtypes and correlates negatively with pathological complete response, and the expression level of FOXC1, another EMT inducer, correlates strongly with poor survival of breast cancer patients. Expand
The pINDUCER lentiviral toolkit for inducible RNA interference in vitro and in vivo
TLDR
The lentiviral pINDUCER series of expression vehicles enable tracking of viral transduction and shRNA or cDNA induction in a broad spectrum of mammalian cell types in vivo and allows isolation of cell populations that exhibit a potent, inducible target knockdown in vitro and in vivo that can be used in human xenotransplantation models to examine cancer drug targets. Expand
The functional loss of the retinoblastoma tumour suppressor is a common event in basal-like and luminal B breast carcinomas
TLDR
The results suggest that the functional loss of RB1 is common in basal-like tumours, which may play a key role in dictating their aggressive biology and unique therapeutic responses. Expand
FOXC2 expression links epithelial-mesenchymal transition and stem cell properties in breast cancer.
TLDR
It is reported that the transcription factor FOXC2 induced in response to multiple EMT signaling pathways as well as elevated in stem cell-en enriched factions is a critical determinant of mesenchymal and stem cell properties, in cells induced to undergo EMT- and CSC-enriched breast cancer cell lines. Expand
Comparative oncogenomics identifies breast tumors enriched in functional tumor-initiating cells
TLDR
Limiting dilution transplantation revealed that p53 null claudin-low tumors are highly enriched for TICs compared with the more common adenocarcinomas arising in the same model, thus providing a unique preclinical mouse model to investigate the therapeutic response of Tics. Expand
Epigenetic silencing of microRNA-203 is required for EMT and cancer stem cell properties
TLDR
The data suggest that restoring miR-203 expression levels may inhibit metastasis and combat deregulated Wnt signaling, and discover essential mediators of EMT-imparted stemness properties. Expand
Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts
TLDR
This study of murine models of breast carcinoma encompasses the largest comprehensive genomic dataset to date to identify human-to-mouse disease subtype counterparts and indicates that multiple genetically engineered mouse models are needed to represent the diversity of human breast cancers. Expand
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