MSMS: a coalescent simulation program including recombination, demographic structure and selection at a single locus
- G. Ewing, J. Hermisson
- BiologyBioinform.
- 30 June 2010
A coalescent simulation program for a structured population with selection at a single diploid locus that includes the functionality of the simulator ms to model population structure and demography, but adds a model for deme- and time-dependent selection using forward simulations.
Soft sweeps II--molecular population genetics of adaptation from recurrent mutation or migration.
- P. Pennings, J. Hermisson
- BiologyMolecular biology and evolution
- 1 May 2006
This study uses analytical calculations based on coalescent theory and computer simulations to analyze molecular adaptation from recurrent mutation or migration, and derives a robust analytical approximation for the number of ancestral haplotypes and their distribution in a sample from the population.
The Population Genetic Theory of Hidden Variation and Genetic Robustness
- J. Hermisson, G. Wagner
- BiologyGenetics
- 1 December 2004
This article introduces an approximation to the genetic variance in mutation-selection-drift balance that includes the previously used stochastic Gaussian and house-of-cards approximations as limiting cases and concludes that the release of hidden genetic variation is a generic property of models with epistasis or genotype-environment interaction, regardless of whether the wild-type genotype is canalized or not.
Soft Sweeps
- J. Hermisson, P. Pennings
- BiologyGenetics
- 1 April 2005
This work uses diffusion theory to calculate the probabilities for selective adaptations and finds a large increase in the fixation probability for weak substitutions, if alleles originate from the standing genetic variation.
PERSPECTIVE:EVOLUTION AND DETECTION OF GENETIC ROBUSTNESS
- J. D. de Visser, J. Hermisson, M. Whitlock
- BiologyEvolution; international journal of organic…
- 1 September 2003
This work focuses on the first kind of robustness—genetic robustness)—and survey three growing avenues of research: measuring genetic robustness in nature and in the laboratory; understanding the evolution of genetic robusts; and exploring the implications of genetic resilientness for future evolution.
Soft Sweeps III: The Signature of Positive Selection from Recurrent Mutation
- P. Pennings, J. Hermisson
- BiologyPLoS Genetics
- 14 September 2006
The effect of adaptation from recurrent mutation on summary statistics for polymorphism data from a linked neutral locus is demonstrated and a variant of existing LD tests is suggested that increases their power to detect this signature.
An Analytically Tractable Model for Competitive Speciation
- P. Pennings, M. Kopp, G. Meszéna, U. Dieckmann, J. Hermisson
- BiologyAmerican Naturalist
- 15 November 2007
The approach provides a mechanistic understanding of several phenomena that have been found in previous models and demonstrates how even in a simple model, the evolutionary outcome depends in a complex way on ecological and genetic parameters.
Mutation-selection balance: ancestry, load, and maximum principle.
- J. Hermisson, O. Redner, H. Wagner, E. Baake
- BiologyTheoretical Population Biology
- 25 February 2002
The results are applied to threshold phenomena caused by the interplay of selection and mutation (known as error thresholds) and lead to a clarification of concepts, as well as criteria for the existence of error thresholds.
Soft sweeps and beyond: Understanding the patterns and probabilities of selection footprints under rapid adaptation
- J. Hermisson, P. Pennings
- BiologybioRxiv
- 7 March 2017
Here, the key theoretical concepts and contrast model predictions with observed patterns in Drosophila, humans, and microbes are summarized and called for in-depth empirical study and further model development.
On the Fixation Process of a Beneficial Mutation in a Variable Environment
- Hildegard Uecker, J. Hermisson
- BiologyGenetics
- 1 August 2011
This work presents a framework to describe the fixation process of a single beneficial allele under these conditions, and derives compact analytical approximations for the fixation probability and the distribution of passage times for the beneficial allele to reach a given intermediate frequency.
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