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Classifying environmental pollutants
Abstract In this paper a scheme is presented that makes it possible to classify a large number of organic pollutants into one of four classes, viz: [1] inert chemicals, [2] less inert chemicals, [3]Expand
QSAR modelling of soil sorption. Improvements and systematics of log KOC vs. log KOW correlations
A systematic study was performed to evaluate the quality and reliability of the quantitative relationships between the soil sorption coefficients and the n-octanol/water partition coefficients (logExpand
Determination of octanol/water partition coefficients for hydrophobic organic chemicals with the “slow‐stirring” method
Experimental data are presented on octanol/water partition coefficients for 70 hydrophobic organic chemicals that were determined with a “slow-stirring” method. With this method, log Kow values canExpand
Modes of action in ecotoxicology: their role in body burdens, species sensitivity, QSARs, and mixture effects.
  • B. Escher, J. Hermens
  • Environmental Science, Medicine
  • Environmental science & technology
  • 11 September 2002
TLDR
This review seeks to show the crucial role of target sites, interactions with the target site(s), and mechanisms for an adequate and efficient ecotoxicological risk assessment and recommends the use of internal effect concentrations and target site concentrations as a mixture toxicity parameter. Expand
Equilibrium sampling devices.
TLDR
These devices are part of an emerging strategy for monitoring exposure to hydrophobic organic chemicals and are designed to provide real-time information about human exposure to these chemicals. Expand
Sensing Dissolved Sediment Porewater Concentrations of Persistent and Bioaccumulative Pollutants Using Disposable Solid-Phase Microextraction Fibers
Polymer coated glass fibers were applied as disposable samplers to measure dissolved concentrations of persistent and bioaccumulative pollutants (PBPs) in sediment porewater. The method is calledExpand
A quantitative property-property relationship (QPPR) approach to estimate in vitro tissue-blood partition coefficients of organic chemicals in rats and humans
TLDR
Signs for a possible role of tissue components other than lipid and water in the tissue-blood partitioning process of compounds were observed from the calibration results of the model. Expand
Measurement of free concentrations using negligible depletion-solid phase microextraction (nd-SPME)
Measurement of free concentration is necessary to determine the effective or bioavailable quantity of a chemical, and is also a way of determining the binding affinity or partition coefficient of aExpand
Dose metric considerations in in vitro assays to improve quantitative in vitro-in vivo dose extrapolations.
TLDR
A number of dose metrics and their dependency on in vitro assay setup are discussed, and recommendations are given on when to consider alternative dose metrics instead of nominal concentrations, in order to reduce effect concentration variability between in vitro assays and between in vivo and in vivo assays in toxicology. Expand
Poly(dimethylsiloxane) as passive sampler material for hydrophobic chemicals: effect of chemical properties and sampler characteristics on partitioning and equilibration times.
TLDR
Equilibration times are predicted for organic chemicals that vary in hydrophobicity and samplers with different dimensions and polymeric phases and a simple diffusion-based model illustrates that the exchange of chemicals was limited by diffusion through the aqueous diffusion layer surrounding the sampler. Expand
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