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The intron-enriched HERV-K(HML-10) family suppresses apoptosis, an indicator of malignant transformation
Its enrichment within introns suggests that HML-10 may have been evolutionary co-opted for gene regulation more than other HERV families, and may contribute to evasion of apoptosis in malignant cells.
Cooperation of Ras- and c-Myc-dependent pathways in regulating the growth and invasiveness of synovial fibroblasts in rheumatoid arthritis.
The data demonstrate that Ras- and c-Myc-dependent signaling events cooperate to regulate the growth and invasiveness of RASFs and targeting of both c-Raf-1 and c -Myc may constitute an interesting therapeutic approach in RA.
A Short Hairpin DNA Analogous to miR-125b Inhibits C-Raf Expression, Proliferation, and Survival of Breast Cancer Cells
- M. Hofmann, J. Heinrich, Gerald Radziwil, K. Moelling
- Biology, ChemistryMolecular Cancer Research
- 1 October 2009
The short hairpin-looped ODN-Raf, targeting the same region of c-raf-1 as miR-125b, is a multifunctional molecule reducing the expression of oncoproteins and stimulating cell death, both features may be useful to interfere with tumor growth.
Antibodies from a DNA peptide vaccination decrease the brain amyloid burden in a mouse model of Alzheimer’s disease
The combined DNA peptide vaccine may prove useful for active immunization with few inoculations and low peptide dose which may prevent the recently described inflammatory reactions in patients.
Short partially double-stranded oligodeoxynucleotide induces reverse transcriptase/RNase H-mediated cleavage of HIV RNA and contributes to abrogation of infectivity of virions.
- A. Matskevich, A. Ziogas, J. Heinrich, Sandra-Annika Quast, K. Moelling
- Biology, ChemistryAIDS research and human retroviruses
- 1 December 2006
A novel mechanism of viral RNA eradication by an oligodeoxynucleotide A (ODN A) directly in HIV virions is described, and the pretreatment with ODN A strongly reduced the infectivity of virions in cell culture in the absence of any DNA carriers or detergents.
Regulation of c‐Src by binding to the PDZ domain of AF‐6
This work has identified a novel type of c‐Src regulation by interaction with a PDZ protein, which is recruited by AF‐6 to cell–cell contact sites, suggesting that cSrc is regulated by a PDz protein in special cellular locations.
RNase H-mediated retrovirus destruction in vivo triggered by oligodeoxynucleotides
- Kathrin Matzen, L. Elzaouk, A. Matskevich, A. Nitzsche, J. Heinrich, K. Moelling
- BiologyNature Biotechnology
- 1 June 2007
The HIV-1 RNase H can be prematurely activated by oligodeoxynucleotides targeting the highly conserved polypurine tract required for second strand DNA synthesis, which inhibits retroviral replication in cell-free HIV particles and newly infected cells, and may be broadly applicable to retroviruses of medical and agricultural importance.
A WD-FYVE protein binds to the kinases Akt and PKCzeta/lambda.
A new binding partner for kinases, located on vesicular structures in specialized cells, which may play a role for the spatial organization of signalling cascades is described.
The PDZ protein MPP2 interacts with c-Src in epithelial cells.