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Inhibition of mitochondrial fusion by α‐synuclein is rescued by PINK1, Parkin and DJ‐1
TLDR
It is demonstrated with in vitro vesicle fusion experiments that αS has an inhibitory function on membrane fusion and mitochondrial fragmentation induced by expression of αS is rescued by coexpression of PINK1, parkin or DJ‐1 but not the PD‐associated mutations Pink1 G309D and parkin Δ1–79 or byDJ‐1 C106A. Expand
UNC-108/RAB-2 and its effector RIC-19 are involved in dense core vesicle maturation in Caenorhabditis elegans
Uncoordinated movement in Rab2 mutants is caused by impaired retention of cargo on dense core vesicles, not by defective synaptic vesicle release. (Also see the companion article by Edwards et al. inExpand
Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth*
TLDR
It is demonstrated that a mutation in the Caenorhabditits elegans homologue of the PTEN-induced kinase pink-1 gene resulted in reduced mitochondrial cristae length and increased paraquat sensitivity of the nematode, and the first evidence of an antagonistic role of PINK-1 and LRK-1 is provided. Expand
Cytoskeletal elements in the bacterium Mycoplasma pneumoniae
TLDR
By application of a modified Triton X-100 treatment, it is demonstrated that M. pneumoniae possesses a cytoskeleton consisting of a blade-like rod and a peripheral lining located close to the inner face of the cytoplasmic membrane, exhibiting features of a highly regular network. Expand
Impaired dense core vesicle maturation in Caenorhabditis elegans mutants lacking Rab2
Uncoordinated movement in Rab2 mutants is caused by impaired retention of cargo on dense core vesicles, not by defective synaptic vesicle release. (Also see the companion article by Sumakovic et al.Expand
Murine and human pluripotent stem cell-derived cardiac bodies form contractile myocardial tissue in vitro.
TLDR
BCT with contractile forces comparable with native myocardium can be generated from enriched, PSC-derived CMs, based on a novel concept of tissue formation from non-dissociated cardiac cell aggregates, which represents a major step towards clinical applicability of stem cell-based heart tissue for myocardial repair. Expand
TFG-1 function in protein secretion and oncogenesis.
TLDR
TFG-1 is identified, a new conserved regulator of protein secretion that interacts directly with SEC-16 and controls the export of cargoes from the endoplasmic reticulum in Caenorhabditis elegans, providing a mechanism by which translocations involving TFG can result in cellular transformation and oncogenesis. Expand
Defining the mycoplasma 'cytoskeleton': the protein composition of the Triton X-100 insoluble fraction of the bacterium Mycoplasma pneumoniae determined by 2-D gel electrophoresis and mass
TLDR
The composition of the Triton X-100 insoluble fraction was defined by electron microscopic screening for possible structural elements, and by two-dimensional gel electrophoresis and MS to identify the proteins present, which included the heat-shock protein DnaK, elongation factor Tu and subunits alpha and beta of the pyruvate dehydrogenase complex. Expand
RAB-5 and RAB-10 cooperate to regulate neuropeptide release in Caenorhabditis elegans
TLDR
It is shown here that the formation of release-competent DCVs requires a reciprocal exclusion cascade coupling RAB-5 and Rab-10, in which each of the two Rabs recruits the other’s GAP molecule. Expand
The endoplasmic reticulum localized PIN8 is a pollen-specific auxin carrier involved in intracellular auxin homeostasis.
TLDR
The data show a functional role for endoplasmic reticulum-localized PIN8 and suggest a mechanism whereby PIN8 controls auxin thresholds and access of auxin to the nucleus, thereby regulating auxin-dependent transcriptional activity. Expand
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