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Mouse models of diabetic neuropathy
The hypothesis that genetic background and diet influence the development of DN is supported and should be considered when developing new models of DN. Expand
Dyslipidemia-Induced Neuropathy in Mice : the Role of oxLDL / LOX-1
This is an uncopyedited electronic version of an article accepted for publication in Diabetes. The American Diabetes Association, publisher of Diabetes, is not responsible for any errors or omissionsExpand
Increased tau phosphorylation and cleavage in mouse models of type 1 and type 2 diabetes.
The results suggest tau modification caused by insulin dysfunction and hyperglycemia may contribute to the increased incidence of AD in diabetes. Expand
Protective Effects of Cyclooxygenase-2 Gene Inactivation Against Peripheral Nerve Dysfunction and Intraepidermal Nerve Fiber Loss in Experimental Diabetes
It is suggested that selective COX-2 inhibition may be useful for preventing or delaying DPN and against nerve fiber loss in diabetic rats. Expand
Human neural stem cell transplantation improves cognition in a murine model of Alzheimer’s disease
The results support further preclinical development of human neural stem cells as a safe and effective therapy for Alzheimer’s disease and suggest integration into native tissue or the idea that transient engraftment may be adequate for therapeutic efficacy, reducing the need for continued immunosuppression. Expand
Nerve Growth Factor Mediates Mechanical Allodynia in a Mouse Model of Type 2 Diabetes
It is found that NGF, SP, and calcitonin gene-related peptide gene expression is upregulated in the dorsal root ganglion of db/db mice before or during the period that they develop mechanical allodynia, and inhibition of NGF action is a potential strategy for treating painful diabetic neuropathy. Expand
Transcriptional Profiling of Diabetic Neuropathy in the BKS db/db Mouse
The data support existing hypotheses regarding hyperglycemia-mediated nerve damage in DN and revealed a possible coregulation mechanism connecting hyperlipidemia and axonal degeneration. Expand
Chronic stress and peripheral pain: Evidence for distinct, region-specific changes in visceral and somatosensory pain regulatory pathways
The data indicate that chronic stress induces visceral and somatosensory hyperalgesia that involves differential changes in endovanilloid and endocannabinoid pathways, and sodium channels in DRGs innervating the pelvic viscera and lower extremities. Expand
Neurodegeneration and early lethality in superoxide dismutase 2-deficient mice: A comprehensive analysis of the central and peripheral nervous systems
The results indicate that targeted neuronal SOD2 knockout using the nestin promoter results in severe central nervous system degeneration and perinatal lethality in mice. Expand
Juvenile murine models of prediabetes and type 2 diabetes develop neuropathy
The mouse models described in this paper provide critical tools to better understand the underlying pathogenesis of prediabetic and diabetic neuropathy from youth to adulthood, and support the idea that hyperglycemia alone does not drive early neuropathy. Expand