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Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy.
CONTEXT The biological basis for the development of major depressive disorder (MDD) remains incompletely understood. OBJECTIVE To quantify brain serotonin (5-hydroxytryptamine [5-HT]) turnover inExpand
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Sympathetic nervous system and insulin resistance: from obesity to diabetes.
As the world faces an obesity "epidemic," the mechanisms by which overweight is translated into insulin resistance, hypertension, and diabetes need to be better understood. Although the processes ofExpand
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Effects of intravenous brain natriuretic peptide on regional sympathetic activity in patients with chronic heart failure as compared with healthy control subjects.
OBJECTIVES We sought to assess the effects of brain natriuretic peptide (BNP) on systemic and regional sympathetic nervous activity (SNA) in both patients with congestive heart failure (CHF) andExpand
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Sympathetic Nerve Biology In Essential Hypertension
1. Although the importance of sympathetic nervous activation in the pathogenesis of essential hypertension is well documented, the exact pathophysiology of the sympathetic nervous dysfunction presentExpand
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Leptin-Receptor Polymorphisms Relate to Obesity through Blunted Leptin-Mediated Sympathetic Nerve Activation in a Caucasian Male Population
Leptin plays a key role in the regulation of body weight through the sympathetic nervous system; however, the contributions of leptin-receptor polymorphisms to obesity and sympathetic nerve activityExpand
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Parenteral nutrition supplemented with short-chain fatty acids: effect on the small-bowel mucosa in normal rats.
When enteral nutrition is excluded from animals maintained solely with total parenteral nutrition (TPN), atrophy of the intestinal mucosa is observed. Short-chain fatty acids (SCFAs) are produced inExpand
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Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function.
The link between the human sympathoadrenalmedullary system and the adipocyte hormone leptin is controversial. We measured total and regional norepinephrine spillover, epinephrine secretion rate, andExpand
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Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats.
It has been demonstrated in the conscious dog that portal glucose infusion creates a signal that increases net hepatic glucose uptake and hepatic glycogen deposition. Experiments leading to anExpand
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Catecholamine release in the rat hypothalamic paraventricular nucleus in response to haemorrhage, desipramine and potassium
In vivo microdialysis and HPLC were used to measure catecholamine release in the rat hypothalamic paraventricular nucleus (PVN) during haemorrhage. The effects of noradrenaline uptake blockade with 1Expand
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The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover.
Investigating aging effects on the sympathetic nervous system and ascertaining underlying central nervous system (CNS) mechanisms mediating sympathetic stimulation is clinically pertinent because ofExpand
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