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Elevated brain serotonin turnover in patients with depression: effect of genotype and therapy.
CONTEXT The biological basis for the development of major depressive disorder (MDD) remains incompletely understood. OBJECTIVE To quantify brain serotonin (5-hydroxytryptamine [5-HT]) turnover in… Expand
Sympathetic nervous system and insulin resistance: from obesity to diabetes.
- M. Esler, M. Rumantir, G. Wiesner, D. Kaye, J. Hastings, G. Lambert
- American journal of hypertension
- 1 November 2001
As the world faces an obesity "epidemic," the mechanisms by which overweight is translated into insulin resistance, hypertension, and diabetes need to be better understood. Although the processes of… Expand
Effects of intravenous brain natriuretic peptide on regional sympathetic activity in patients with chronic heart failure as compared with healthy control subjects.
- H. P. Brunner-La Rocca, D. Kaye, R. Woods, J. Hastings, M. Esler
- Journal of the American College of Cardiology
- 1 April 2001
OBJECTIVES We sought to assess the effects of brain natriuretic peptide (BNP) on systemic and regional sympathetic nervous activity (SNA) in both patients with congestive heart failure (CHF) and… Expand
Sympathetic Nerve Biology In Essential Hypertension
- M. Esler, M. Rumantir, +4 authors G. Lambert
- Clinical and experimental pharmacology…
- 1 December 2001
1. Although the importance of sympathetic nervous activation in the pathogenesis of essential hypertension is well documented, the exact pathophysiology of the sympathetic nervous dysfunction present… Expand
Leptin-Receptor Polymorphisms Relate to Obesity through Blunted Leptin-Mediated Sympathetic Nerve Activation in a Caucasian Male Population
Leptin plays a key role in the regulation of body weight through the sympathetic nervous system; however, the contributions of leptin-receptor polymorphisms to obesity and sympathetic nerve activity… Expand
Parenteral nutrition supplemented with short-chain fatty acids: effect on the small-bowel mucosa in normal rats.
- M. Koruda, R. Rolandelli, D. Bliss, J. Hastings, J. Rombeau, R. Settle
- Biology, Medicine
- The American journal of clinical nutrition
- 1 April 1990
When enteral nutrition is excluded from animals maintained solely with total parenteral nutrition (TPN), atrophy of the intestinal mucosa is observed. Short-chain fatty acids (SCFAs) are produced in… Expand
Extra-adipocyte leptin release in human obesity and its relation to sympathoadrenal function.
- N. Eikelis, G. Lambert, +6 authors M. Esler
- American journal of physiology. Endocrinology and…
- 1 May 2004
The link between the human sympathoadrenalmedullary system and the adipocyte hormone leptin is controversial. We measured total and regional norepinephrine spillover, epinephrine secretion rate, and… Expand
Portal glucose infusion increases hepatic glycogen deposition in conscious unrestrained rats.
- S. Cardin, M. Emshwiller, +4 authors A. Cherrington
- Journal of applied physiology
- 1 October 1999
It has been demonstrated in the conscious dog that portal glucose infusion creates a signal that increases net hepatic glucose uptake and hepatic glycogen deposition. Experiments leading to an… Expand
Catecholamine release in the rat hypothalamic paraventricular nucleus in response to haemorrhage, desipramine and potassium
In vivo microdialysis and HPLC were used to measure catecholamine release in the rat hypothalamic paraventricular nucleus (PVN) during haemorrhage. The effects of noradrenaline uptake blockade with 1… Expand
The influence of aging on the human sympathetic nervous system and brain norepinephrine turnover.
- M. Esler, J. Hastings, G. Lambert, D. Kaye, G. Jennings, D. Seals
- Psychology, Medicine
- American journal of physiology. Regulatory…
- 1 March 2002
Investigating aging effects on the sympathetic nervous system and ascertaining underlying central nervous system (CNS) mechanisms mediating sympathetic stimulation is clinically pertinent because of… Expand