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Conditioned fear to context is associated with increased Fos expression in the caudal ventrolateral region of the midbrain periaqueductal gray.
RX 821002 as a tool for physiological investigation of alpha(2)-adrenoceptors.
The careful use of RX 821002 has revealed several aspects of the physiological activity of alpha(2)-adrenoceptors in rabbit spinal cord and rat brain, and it is recommended that yohimbine or idazoxan should be used in preference to atipamezole in all future studies of this type.
Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems
Activation of spinal cannabinoid 1 receptors inhibits C‐fibre driven hyperexcitable neuronal responses and increases [35S]GTPγS binding in the dorsal horn of the spinal cord of noninflamed and…
- L. Drew, J. Harris, P. Millns, D. Kendall, V. Chapman
- Biology, ChemistryThe European journal of neuroscience
- 1 June 2000
Sustained, but not enhanced, antinociceptive effects of HU210 following carrageenin inflammation are reported, strengthening the body of evidence suggesting CB agonists may be an important novel analgesic approach for the treatment of sustained pain states.
Spinal 5‐HT‐receptors and tonic modulation of transmission through a withdrawal reflex pathway in the decerebrated rabbit
5‐HT tonically inhibits transmission between sural nerve afferents and gastrocnemius motoneurones by an action at spinal 5‐HT1A‐receptors, consistent with the idea that, in the decerebrated rabbit, 5‐ HT released from descending axons has multiple roles in controlling transmission through the sural‐gastrocnenemius medialis reflex pathway.
Prolonged inhibition of a spinal reflex after intense stimulation of distant peripheral nerves in the decerebrated rabbit.
- J. S. Taylor, R. Neal, J. Harris, T. Ford, R. Clarke
- Biology, MedicineThe Journal of physiology
- 1 June 1991
Data show that prolonged inhibition of the sural‐GM reflex can be evoked by stimulation of nerves in all four limbs and that in each case the inhibition can be blocked or reduced by co‐administration of antagonists to opioid and alpha 2‐adrenergic receptors.
Glutamate and tachykinin receptors in central sensitization of withdrawal reflexes in the decerebrated rabbit
- J. Harris, C. Joules, C. Stanley, P. Thomas, R. Clarke
- Biology, MedicineExperimental physiology
- 1 March 2004
The present data confirm the importance of NMDA receptors as a critical part of the process of central sensitization, provide no evidence for a role of metabotropic glutamate receptors, and show that simultaneous blockade of all tachykinin receptors is required to reveal their role in hyperalgesia.
Dehydroepiandrosterone sulfate (DHEAS) counteracts decremental effects of corticosterone on dentate gyrus LTP. implications for depression
Dose–Response Study of Dehydroepiandrosterone Sulfate on Dentate Gyrus Long Term Potentiation
A significant increase in LTP at all doses in relation to baseline values was showed, and there were significant increments in amplitude at 20 and 30 mg in comparison to 10 mg, however, the data did not reveal significant differences between the 20- and the 30-mg-treated rats.
Spinal anandamide inhibits nociceptive transmission via cannabinoid receptor activation in vivo
Spinal anandamide inhibited nociceptive transmission via CB1 receptors; following inflammation there is evidence for a loss of spinal endogenous cannabinoid tone.