J. Harper

Publications114
h-index40
Citations6,745
Highly Influential Citations187
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Theory of ripple topography induced by ion bombardment
When an amorphous solid is etched by an off‐normal incidence ion beam, a ripple topography often results. A theory explaining the origin of these waves is presented. For incidence angles close to the… Expand
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Methionine‐deficient diet extends mouse lifespan, slows immune and lens aging, alters glucose, T4, IGF‐I and insulin levels, and increases hepatocyte MIF levels and stress resistance
A diet deficient in the amino acid methionine has previously been shown to extend lifespan in several stocks of inbred rats. We report here that a methionine‐deficient (Meth‐R) diet also increases… Expand
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Does caloric restriction extend life in wild mice?
To investigate whether mice genetically unaltered by many generations of laboratory selection exhibit similar hormonal and demographic responses to caloric restriction (CR) as laboratory rodents, we… Expand
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CXCL12 Limits Inflammation by Localizing Mononuclear Infiltrates to the Perivascular Space during Experimental Autoimmune Encephalomyelitis1
The inflammatory response in the CNS begins with the movement of leukocytes across the blood-brain barrier in a multistep process that requires cells to pass through a perivascular space before… Expand
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Fecal Glucocorticoids: A Noninvasive Method of Measuring Adrenal Activity in Wild and Captive Rodents
To determine the utility of fecal corticosteroid concentration as a measure of chronic stress under laboratory and field conditions, we biochemically and physiologically validated a radioimmunoassay… Expand
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Skin‐derived fibroblasts from long‐lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone
Fibroblast cell lines were developed from skin biopsies of eight species of wild‐trapped rodents, one species of bat, and a group of genetically heterogeneous laboratory mice. Each cell line was… Expand
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Big mice die young: early life body weight predicts longevity in genetically heterogeneous mice
Small body size has been associated with long life span in four stocks of mutant dwarf mice, and in two varieties of dietary restriction in rodents. In this study, small body size at ages 2–24 months… Expand
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Longer Life Spans and Delayed Maturation in Wild-Derived Mice
Nearly all the experimental mice used in aging research are derived from lineages that have been selected for many generations for adaptation to laboratory breeding conditions and are subsequently… Expand
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Extended longevity of wild-derived mice is associated with peroxidation-resistant membranes
Two lines of mice, Idaho (Id) and Majuro (Ma), both derived from wild-trapped progenitors, have previously been shown to have extended lifespans in captivity when compared to a genetically… Expand
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Functional linkages for the pace of life, life-history, and environment in birds.
For vertebrates, body mass underlies much of the variation in metabolism, but among animals of the same body mass, metabolism varies six-fold. Understanding how natural selection can influence… Expand
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