• Publications
  • Influence
Hospital volume can serve as a surrogate for surgeon volume for achieving excellent outcomes in colorectal resection.
TLDR
A skewed distribution of case volumes by surgeon was found in this study of patients who underwent resection for large bowel cancer in Maryland, with higher surgeon volume associated with significant improvement in all three outcomes (in-hospital death, length of stay, and cost). Expand
Dextran hydrogel scaffolds enhance angiogenic responses and promote complete skin regeneration during burn wound healing
TLDR
Customized dextran-based hydrogel alone, with no additional growth factors, cytokines, or cells, promoted remarkable neovascularization and skin regeneration and may lead to novel treatments for dermal wounds. Expand
Aberrant epithelial-mesenchymal Hedgehog signaling characterizes Barrett's metaplasia.
TLDR
Epithelial Hedgehog ligand expression may contribute to the initiation of Barrett's esophagus through induction of stromal BMP4, which triggers reprogramming of esophageal epithelium in favor of a columnar phenotype. Expand
Age‐dependent impairment of HIF‐1α expression in diabetic mice: Correction with electroporation‐facilitated gene therapy increases wound healing, angiogenesis, and circulating angiogenic cells
TLDR
HIF‐1α gene therapy corrects the age-dependent impairment of HIF‐ 1α expression, angiogenic cytokine expression, and CACs that contribute to the age‐ dependent impairment of wound healing in db/db mice. Expand
A laboratory model for studying blast overpressure injury.
TLDR
The blast wave generator permits reproducible blast injury in the laboratory that is safer and faster than current methods, and the lung and bowel lesions induced are grossly and microscopically similar to injuries of blast exposure seen in clinical patients. Expand
The Role of Magnetic Resonance Cholangiography in the Management of Patients With Gallstone Pancreatitis
TLDR
It is demonstrated that MRC can accurately identify CBD stones preoperatively in patients with gallstone pancreatitis and provide valuable information with respect to other biliary pathology, including cholelithiasis, acute cholecystitis, and pancreatitis. Expand
Effect of growth factors on cell proliferation and epithelialization in human skin.
TLDR
It is postulate that FGF, IGF-1, and EGF are important mitogens for wound healing and that EGF in particular is capable of stimulating epithelialization. Expand
Utility of magnetic resonance cholangiography in the evaluation of biliary obstruction.
TLDR
Magnetic resonance cholangiography may prove to be an important noninvasive tool in preoperative evaluation of patients with suspected biliary obstruction and identification of patients most likely to benefit from an invasive radiologic or surgical procedure. Expand
Endothelial expression of hypoxia-inducible factor 1 protects the murine heart and aorta from pressure overload by suppression of TGF-β signaling
TLDR
It is reported that Hif1af/f;Tie2-Cre conditional knockout mice, which lack HIF-1α expression only in Tie2+ lineage cells, develop normally, but when subjected to pressure overload induced by transaortic constriction, they manifest rapid cardiac decompensation. Expand
Impaired angiogenesis and mobilization of circulating angiogenic cells in HIF‐1α heterozygous‐null mice after burn wounding
TLDR
A signaling pathway by which HIF‐1 promotes angiogenesis during burn wound healing is delineated by mice subjected to a thermal injury involving 10% of the body surface area. Expand
...
1
2
3
4
5
...