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  • Influence
Environmental Health Perspectives
A review of fibrogenesis by asbestos fibers is given. There is nothing to indicate that the fibrogenic effects of inhaled asbestos fibers should differ in any way from those of ingested asbestos.Expand
AN EXAMINATION OF THE CYTOTOXIC EFFECTS OF SILICA ON MACROPHAGES
TLDR
It is suggested that repeated cycles of macrophage killing in vivo leads to the mobilization of fibroblasts and fibrogenesis characterizing the disease silicosis. Expand
Quartz hemolysis as related to its surface functionalities.
TLDR
The surface of quartz is clearly bifunctional, and the ratio of sites is dependent on the degree of ionization of the silanol groups, and both bonding mechanisms are observed to be separate functionalities and must be taken into account to explain membrane activity. Expand
Mineral fibers: chemical, physicochemical, and biological properties.
TLDR
This chapter discusses the chemical, physicochemical, and biological properties of mineral fibers, which are inhaled by miners and exposed industrial workers and are among the most important occupational air pollutants. Expand
A spatial and temporal analysis of four cancers in African gold miners from Southern Africa.
TLDR
Analysis of the spatial distribution of cancer in African gold miners over the 8-year period 1964-71 showed distinct gradients of occurrence between areas of significantly higher and lower incidence than expected. Expand
Fibrogenesis
  • J. Harington
  • Medicine
  • Environmental health perspectives
  • 1 December 1974
TLDR
Recent studies described in the first section of the present review appear to offer a better understanding of the effects of macrophages on fibroblasts after tissue damage of various kinds has occurred. Expand
Haemolytic Activity of Asbestos and other Mineral Dusts
TLDR
It is shown that chrysotile asbestos is as potent a haemolytic agent as silica powder, and other forms of asbestos lysed erythrocytes only after prolonged incubation with them, and a wide range of mineral dusts was inactive. Expand
The sulfhydryl group and carcinogenesis.
  • J. Harington
  • Biology, Medicine
  • Advances in cancer research
  • 1967
TLDR
This chapter examines the reactions of carcinogens with sulfhydryl group (SH) groups in vivo and in vitro and discusses the de novo synthesis of glutathione and certain SH containing acid-soluble materials during the SH-SS cycle. Expand
CYTOTOXIC EFFECTS OF SOME MINERAL DUSTS ON SYRIAN HAMSTER PERITONEAL MACROPHAGES
TLDR
Of the three different kinds of asbestos used, chrysotile was toxic and amosite and crocidolite nontoxic at equivalent concentrations and a comparison of two preparations of chrysOTile showed that weight rather than surface area determines toxicity. Expand
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