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A method for assessing drug therapy appropriateness.
This study evaluated the reliability of a new medication appropriateness index. Using the index, independent assessments were made of chronic medications taken by 10 ambulatory, elderly male patientsExpand
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Clinical consequences of polypharmacy in elderly
Introduction: Polypharmacy, defined as the use of multiple drugs or more than are medically necessary, is a growing concern for older adults. MEDLINE and EMBASE databases were searched from JanuaryExpand
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Polypharmacy in elderly patients.
BACKGROUND Polypharmacy (ie, the use of multiple medications and/or the administration of more medications than are clinically indicated, representing unnecessary drug use) is common among theExpand
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A drug burden index to define the functional burden of medications in older people.
BACKGROUND Older people carry a high burden of illness for which medications are indicated, along with increased risk of adverse drug reactions. We developed an index to determine drug burden basedExpand
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Appropriate prescribing in elderly people: how well can it be measured and optimised?
Prescription of medicines is a fundamental component of the care of elderly people, and optimisation of drug prescribing for this group of patients has become an important public-health issueExpand
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A randomized, controlled trial of a clinical pharmacist intervention to improve inappropriate prescribing in elderly outpatients with polypharmacy.
PURPOSE To evaluate the effect of sustained clinical pharmacist interventions involving elderly outpatients with polypharmacy and their primary physicians. PATIENTS AND METHODS Randomized,Expand
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Cumulative use of strong anticholinergics and incident dementia: a prospective cohort study.
IMPORTANCE Many medications have anticholinergic effects. In general, anticholinergic-induced cognitive impairment is considered reversible on discontinuation of anticholinergic therapy. However, aExpand
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Adverse Drug Events In High Risk Older Outpatients
OBJECTIVE: To describe the prevalence, types, and consequences of adverse drug events (ADEs) in older outpatients with polypharmacy.
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A summated score for the medication appropriateness index: development and assessment of clinimetric properties including content validity.
Inappropriate medication prescribing is an important problem in the elderly, but is difficult to measure. As part of a randomized controlled trial to evaluate the effectiveness of a pharmacistExpand
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Central nervous system active medications and risk for fractures in older women.
BACKGROUND Use of central nervous system (CNS) active medications may increase the risk for fractures. Prior studies are limited by incomplete control of confounders. METHODS To determine whetherExpand
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