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The JC virus antibody response in serum and cerebrospinal fluid in progressive multifocal leucoencephalopathy.
BACKGROUND A clinical diagnosis of progressive multifocal leucoencephalopathy (PML) can be confirmed by histological or virological examination of brain material. Whilst a less invasive method isExpand
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Detection of JC virus DNA in the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy
JC virus (JCV) DNA was detected by polymerase chain reaction (PCR) amplification in the cerebrospinal fluid (CSF) of 10 of 13 patients with a diagnosis of progressive multifocal leukoencephalopathyExpand
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Prevalence of long‐term BK and JC excretion in HIV‐infected adults and lack of correlation with serological markers
The natural history of polyomavirus infection, and sensitivity of diagnostic assays remain unclear. A stratified group of 94 human immunodeficiency virus (HIV)‐infected patients was studied for bothExpand
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A simplified and standardized neutralization enzyme immunoassay for the quantification of measles neutralizing antibody.
A simplified and standardized neutralization enzyme immunoassay (Nt-EIA) was developed to detect measles virus growth in Vero cells and to quantify measles neutralizing antibody. Heat-inactivatedExpand
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Interaction of the NH2-terminal Domain of Fibronectin with Heparin
Determinants of the interaction of the 29-kDa NH2-terminal domain of fibronectin with heparin were explored by analysis of normal and mutant recombinant NH2-terminal fibronectin fragments produced inExpand
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An M-antibody capture radioimmunoassay (MACRIA) for detection of JC virus-specific IgM.
A solid-phase M-antibody capture radioimmunoassay (MACRIA) for detecting JC-specific IgM is described. The assay is based on a JC-specific monoclonal antibody (17.7.6) and Nonidet P40-treated,Expand
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Preparation of monoclonal antibodies to JC virus and their use in the diagnosis of progressive multifocal leucoeneephalopathy
Seven monoclonal antibodies (MAbs) to polyomavirus JC were produced, and one was selected for use in immunofluorescence (IF) tests on brain material from patients with suspected progressiveExpand
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Characterization of a new polyomavirus (Polyomavirus papionis-2) isolated from baboon kidney cell cultures
SummaryViruses with papovavirus morphology were seen in fluids from baboon kidney cell cultures on three separate occasions (isolates A, B, and C). The size of the virions, 47.9 nm, placed the virusExpand
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Preparation of monoclonal antibodies to JC virus and their use in the diagnosis of progressive multifocal leucoencephalopathy.
Seven monoclonal antibodies (MAbs) to polyomavirus JC were produced, and one was selected for use in immunofluorescence (IF) tests on brain material from patients with suspected progressiveExpand
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81 Inclusion of PD-L1-expressing tumor cells in the combined positive score algorithm yields superior identification of positive specimens around diagnostic cut-offs across multiple indications
Background PD-L1 IHC 22C3 pharmDx uses Tumor Proportion Score (TPS) and Combined Positive Score (CPS) scoring algorithms for the immunohistochemical (IHC) evaluation of PD-L1 protein expression inExpand
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