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Responsiveness to respiratory syncytial virus in neonates is mediated through thymic stromal lymphopoietin and OX40 ligand.
BACKGROUND Recent studies revealed a critical role for thymic stromal lymphopoietin (TSLP) released from epithelial cells and OX40 ligand (OX40L) expressed on dendritic cells (DCs) in T(H)2 primingExpand
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Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.
  • D. Guo, J. Han, +6 authors C. Wang
  • Biology, Medicine
  • Biochemical and biophysical research…
  • 2 December 2005
The substrates of SUMO4, a novel member for the SUMO gene family, were characterized in HEK293 cells cultured under serum starvation by proteomic analysis. We identified 90 SUMO4 substrates includingExpand
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1,25D3 prevents CD8+Tc2 skewing and asthma development through VDR binding changes to the Cyp11a1 promoter
Effector CD8+ T cells convert from IFN-γ+ (Tc1) to IL-13+ (Tc2) cells in the presence of IL-4. Underlying regulatory mechanisms are not fully defined. Here, we show that addition of 1,25D3, theExpand
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Montelukast during primary infection prevents airway hyperresponsiveness and inflammation after reinfection with respiratory syncytial virus.
  • J. Han, Y. Jia, +4 authors E. Gelfand
  • Medicine
  • American journal of respiratory and critical care…
  • 15 August 2010
RATIONALE Respiratory syncytial virus (RSV) bronchiolitis in infants may be followed by the development of asthma-like symptoms. Age at first infection dictates consequences upon reinfection.Expand
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Inhibition of Pim1 kinase prevents peanut allergy by enhancing Runx3 expression and suppressing T(H)2 and T(H)17 T-cell differentiation.
BACKGROUND The provirus integration site for Moloney murine leukemia virus (Pim) 1 kinase is an oncogenic serine/threonine kinase implicated in cytokine-induced cell signaling, whereas Runt-relatedExpand
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The steroidogenic enzyme Cyp11a1 is essential for development of peanut-induced intestinal anaphylaxis.
BACKGROUND Cytochrome P450, family 11, subfamily A, polypeptide 1 (Cyp11a1), a cytochrome P450 enzyme, is the first and rate-limiting enzyme in the steroidogenic pathway, converting cholesterol toExpand
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The Role of RSV Infection in Asthma Initiation and Progression: Findings in a Mouse Model
Respiratory syncytial virus (RSV) is a common cause of severe lower respiratory tract diseases (bronchiolitis and pneumonia) during infancy and early childhood. There is increasing evidence whichExpand
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C-terminal part of α-synuclein mediates its activity in promoting proliferation of dopaminergic cells
Although abnormal aggregation of α-synuclein (α-syn) is involved in several neurodegenerative diseases, its biological functions remain poorly understood, which limits our understanding of itsExpand
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Effects of anti-g and anti-f antibodies on airway function after respiratory syncytial virus infection.
Respiratory syncytial virus (RSV) is the leading cause of lower respiratory tract illnesses in infants worldwide. Both RSV-G and RSV-F glycoproteins play pathogenic roles during infection with RSV.Expand
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Eosinophils contribute to the resolution of lung-allergic responses following repeated allergen challenge.
BACKGROUND Eosinophils accumulate at the site of allergic inflammation and are critical effector cells in allergic diseases. Recent studies have also suggested a role for eosinophils in theExpand
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