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A recombinant Eimeria protein inducing interferon-gamma production: comparison of different gene expression systems and immunization strategies for vaccination against coccidiosis.
A rabbit antiserum against an 18- to 27-kD native protein fraction (F3) from Eimeria acervulina merozoites identified a cDNA (3-1E) containing a 1086-base pair insertion with an open reading frame ofExpand
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Derivation and characterization of pluripotent embryonic germ cells in chicken
  • T. Park, J. Han
  • Medicine, Biology
  • Molecular reproduction and development
  • 1 August 2000
Embryonic germ (EG) cell lines established from primordial germ cells (PGCs) are undifferentiated and pluripotent stem cells. To date, EG cells with proven germ‐line transmission have been completelyExpand
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Targeted gene knockout in chickens mediated by TALENs
Significance Targeted gene knockout by editing specific loci in genome has revolutionized the field of functional genomics. Transcription activator-like effector nucleases (TALENs) are representativeExpand
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piggyBac transposition into primordial germ cells is an efficient tool for transgenesis in chickens
  • T. S. Park, J. Han
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 29 May 2012
Transgenic birds embody one of the most potent and exciting research tools in biotechnology for agriculture, medicine, and model animals. To date, retrovirus- or lentivirus-mediated transgenesis hasExpand
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PRODUCTION OF GERMLINE CHIMERIC CHICKENS BY TRANSFER OF CULTURED PRIMORDIAL GERM CELLS
Primordial germ cells (PGCs) from stage 27 (5.5‐day‐old) Korean native ogol chicken embryonic germinal ridges were cultured in vitro for 5 days. As in in vivo culture, these cultured PGCs wereExpand
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MicroRNA-mediated posttranscriptional regulation is required for maintaining undifferentiated properties of blastoderm and primordial germ cells in chickens
  • S. Lee, B. Lee, +5 authors J. Han
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 13 June 2011
MicroRNAs (miRNAs) play a critical role in determining the differentiation fate of pluripotent stem cells and germ cells in mammals. However, the mechanism(s) of miRNA-mediated posttranscriptionalExpand
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Human papillomavirus type 16 E5 oncoprotein as a new target for cervical cancer treatment.
Human papillomavirus (HPV) infection is considered to be the necessary cause of cervical cancer. E6 and E7 oncoproteins of HPV have been known to play major roles in malignant transformation ofExpand
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Embryonic stem cell-like cells established by culture of adult ovarian cells in mice.
OBJECTIVE To suggest an alternative strategy for deriving histocompatible stems cells without undertaking genetic manipulation. DESIGN Prospective approach using an animal model. SETTING StemExpand
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Production of germline chimeras by transfer of chicken gonadal primordial germ cells maintained in vitro for an extended period.
We previously reported that germline chimeras could be produced by transfer of chicken gonadal primordial germ cells (gPGCs) cultured for a short term (5 days). This study was subsequently undertakenExpand
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Development of Novel Markers for the Characterization of Chicken Primordial Germ Cells
This study was undertaken to develop novel markers for chicken primordial germ cells (PGCs), which are of potentially enormous value in transgenic research. Gonadal cells collected from 5.5‐day‐oldExpand
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