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Systematic validation of specific phenotypic markers for in vitro polarized human macrophages.
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Sticky Signaling—Adhesion Class G Protein–Coupled Receptors Take the Stage
TLDR
This review discusses the currently available data regarding the main structural elements of Adhesion-GPCRs in the context of receptor function and signaling and indicates that a juxtamembrane GPCR autoproteolysis-inducing domain containing the G PCR proteolysis site (GPS) figures prominently in the biological function of Ad cohesion-G PCRs.
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Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
TLDR
This work analyzes and compares the transcriptome and proteome of human and murine macrophages under resting conditions (M0) and after IL-4 activation (M2) and provides a resource for tools enabling macrophage detection in human tissues by identifying a set of 87 Macrophage-related genes.
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International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors
TLDR
This review covers all major biologic aspects of Adhesion GPCRs, including evolutionary origins, interaction partners, signaling, expression, physiologic functions, and therapeutic potential.
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The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)
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The epidermal growth factor-like domains of the human EMR2 receptor mediate cell attachment through chondroitin sulfate glycosaminoglycans.
TLDR
This is the first report of a GAG ligand for the TM7 receptors extending the already vast repertoire of stimuli of the GPCR superfamily.
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CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets
TLDR
The absence of the TNF-receptor family member CD27 marks the stable acquisition of cytolytic effector functions by both CD4+ and CD8+ T cells, and the definition of cytotoxic effector cells within the known mature NK cell subsets in humans is defined.
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Human EMR2, a novel EGF-TM7 molecule on chromosome 19p13.1, is closely related to CD97.
TLDR
A new member of the EGF-TM7 family, EMR2, which shares strikingly similar molecular characteristics with CD97, is described and may have a unique function in cells of monocyte/Mφ and granulocyte lineages.
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F4/80 and the related adhesion‐GPCRs
TLDR
This Viewpoint summarises current knowledge of the expression, structure and functions of the EGF‐TM7 family, as part of a larger family of tissue adhesion‐GPCRs.
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Tissue-resident memory T cells populate the human brain
TLDR
It is concluded that the human brain is surveilled by TRM cells, providing protection against neurotropic virus reactivation, whilst being under tight control of key immune checkpoint molecules.
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