Regulation of Muscle Fiber Type and Running Endurance by PPARδ
- Yong-Xu Wang, Chun-li Zhang, R. Evans
- BiologyPLoS Biology
- 24 August 2004
The engineering of a mouse capable of continuous running of up to twice the distance of a wild-type littermate is described, achieved by targeted expression of an activated form of peroxisome proliferator-activated receptor δ (PPARδ) in skeletal muscle, which induces a switch to form increased numbers of type I muscle fibers.
Peroxisome-Proliferator-Activated Receptor δ Activates Fat Metabolism to Prevent Obesity
- Yong-Xu Wang, Chih‐Hao Lee, R. Evans
- BiologyCell
- 18 April 2003
Peroxisome-proliferator-activated receptor delta activates fat metabolism to prevent obesity.
- Yong-Xu Wang, Chih‐Hao Lee, R. Evans
- BiologyCell
- 2003
It is shown here that targeted activation of PPARdelta in adipose tissue specifically induces expression of genes required for fatty acid oxidation and energy dissipation, which in turn leads to improved lipid profiles and reduced adiposity.
PPARδ regulates glucose metabolism and insulin sensitivity
- Chih‐Hao Lee, P. Olson, R. Evans
- Biology, Medicine
- 28 February 2006
It is shown that PPARδ (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db mice improves insulin sensitivity, and gene array and functional analyses suggest that PParδ ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis.
Activated Liver X Receptors Stimulate Adipocyte Differentiation through Induction of Peroxisome Proliferator-Activated Receptor γ Expression
- Jong Bae Seo, H. M. Moon, J. B. Kim
- BiologyMolecular and Cellular Biology
- 15 April 2004
It is shown that LXR activation stimulated the execution of adipogenesis, as determined by lipid droplet accumulation and adipocyte-specific gene expression in vivo and in vitro.
PPARdelta regulates glucose metabolism and insulin sensitivity.
- Chih‐Hao Lee, P. Olson, R. Evans
- Biology, MedicineProceedings of the National Academy of Sciences…
- 2006
It is shown that PPARdelta (NR1C2) knockout mice are metabolically less active and glucose-intolerant, whereas receptor activation in db/db mice improves insulin sensitivity, and gene array and functional analyses suggest that PPARI ameliorates hyperglycemia by increasing glucose flux through the pentose phosphate pathway and enhancing fatty acid synthesis.
Assessment of antiviral potencies of cannabinoids against SARS-CoV-2 using computational and in vitro approaches
- V. Raj, Jae Gyu Park, Jintae Lee
- Biology, ChemistryInternational Journal of Biological…
- 5 December 2020
Stereospecific anticancer effects of ginsenoside Rg3 epimers isolated from heat-processed American ginseng on human gastric cancer cell
- E. Park, Young-Joo Kim, K. Kang
- Biology, MedicineJournal of Ginseng Research
- 11 December 2013
Activating Signal Cointegrator 2 Required for Liver Lipid Metabolism Mediated by Liver X Receptors in Mice
- Seung-Whan Kim, Keunhee Park, J. W. Lee
- Biology, ChemistryMolecular and Cellular Biology
- 15 May 2003
These results identify ASC-2 as a physiologically important transcriptional coactivator of LXRs and demonstrate its pivotal role in the liver lipid metabolism.
Antibiofilm and Antivirulence Activities of 6-Gingerol and 6-Shogaol Against Candida albicans Due to Hyphal Inhibition
- Jin‐Hyung Lee, Yong-Guy Kim, Pilju Choi, J. Ham, Jae Gyu Park, Jintae Lee
- BiologyFrontiers in Cellular and Infection Microbiology
- 28 August 2018
Results highlight the antibiofilm and antivirulence activities of the ginger components, 6-gingerol and 6-shogaol, against a drug resistant C. albicans strain.
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