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Got milk? The secret life of laticifers.
The anatomy, development and physiology of laticifers are discussed with a focus on evolutionary and ecological perspectives. Expand
Hydroxycinnamic acid amide metabolism: physiology and biochemistry
Hydroxycinnamic acid amides (HCAAs) are a widely distributed group of plant secondary metabolites purported to function in several growth and developmental processes including floral induction,… Expand
Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world.
The growing repository of BIA biosynthetic genes is providing the parts required to apply emerging synthetic biology platforms to the development of production systems in microbes as an alternative to plants as a commecial source of valuable BIAs. Expand
Plant metabolomics: analytical platforms and integration with functional genomics
As the final downstream product of the genome, the plant metabolome is a highly complex, dynamic assortment of primary and secondary compounds. Although technological platforms to study genomes,… Expand
Dioxygenases catalyze the O-demethylation steps of morphine biosynthesis in opium poppy.
Two previously undetected enzymes involved in morphine biosynthesis and unique among plants to opium poppy have been identified as non-heme dioxygenases, in contrast to the functionally analogous… Expand
Elevated tyrosine decarboxylase and tyramine hydroxycinnamoyltransferase levels increase wound-induced tyramine-derived hydroxycinnamic acid amide accumulation in transgenic tobacco leaves
The rate of wound-induced HCAAT accumulation was highest in transgenic plants with elevated THT and TYDC activities showing that both enzymes exert control over the flux of intermediates involved in H CAAT biosynthesis under some conditions. Expand
Biosynthesis of amphetamine analogs in plants.
- J. Hagel, R. Krizevski, F. Marsolais, E. Lewinsohn, P. Facchini
- Biology, Medicine
- Trends in plant science
- 1 July 2012
The isolation of enzymes with the serendipitous capacity to accept novel substrates could allow the production of substituted amphetamines in synthetic biosystems. Expand
Transcriptome Profiling of Khat (Catha edulis) and Ephedra sinica Reveals Gene Candidates Potentially Involved in Amphetamine-Type Alkaloid Biosynthesis
Data-mining frameworks for Ephedra sinica and khat plants are established and enzymes with established roles in benzoic acid metabolism, as well as enzymes catalyzing reactions similar to those predicted for amphetamine alkaloid metabolism are mined. Expand
Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants
- J. Hagel, Jeremy S Morris, +9 authors P. Facchini
- Medicine, Biology
- BMC Plant Biology
- 18 September 2015
This study establishes an essential resource for the isolation and discovery of 1) functional homologues and 2) entirely novel catalysts within BIA metabolism. Expand
Expressed sequence tag analysis of khat (Catha edulis) provides a putative molecular biochemical basis for the biosynthesis of phenylpropylamino alkaloids
- J. Hagel, R. Krizevski, +4 authors P. Facchini
- Biology, Medicine
- Genetics and molecular biology
- 1 October 2011
A cDNA library from young khat leaves was prepared and candidates potentially involved at various stages of phenylpropylamino alkaloid biosynthesis from L-phenylalanine to (1S,2S)-cathine were identified. Expand