J. Ha

Publications89
h-index16
Citations978
Highly Influential Citations16
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Peripherally inserted veno-venous ultrafiltration for rapid treatment of volume overloaded patients.
BACKGROUND Veno-venous ultrafiltration may benefit patients with acute or chronic circulatory volume overload. Use of conventional systems, however, may be cumbersome, requiring physician placement… Expand
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Synthesis and biological evaluation of rhodanine derivatives as PRL-3 inhibitors.
A series of rhodanine derivatives was synthesized and evaluated for their ability to inhibit PRL-3. Benzylidene rhodanine derivative showed good biological activity, while compound 5e was the most… Expand
  • 97
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Synthesis and PTP1B inhibition of 1,2-naphthoquinone derivatives as potent anti-diabetic agents.
A new series of 1,2-naphthoquinone derivatives was synthesized by various synthetic methods and evaluated for their ability to inhibit protein tyrosine phosphatase 1B (PTP1B). 1,2-Naphthoquinone… Expand
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Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects.
SIRT1 and SIRT2 are deacetylase enzymes that belong to the sirtuin family and are involved in tumorigenesis. In our screen for small molecules inhibiting SIRT1/2 toxoflavin was identified. Toxoflavin… Expand
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A novel cereblon modulator for targeted protein degradation.
  • S. Kim, Ara Go, +14 authors J. Hwang
  • Chemistry, Medicine
  • European journal of medicinal chemistry
  • 15 March 2019
Immunomodulatory drugs (IMiDs) exert anti-myeloma activity by binding to the protein cereblon (CRBN) and subsequently degrading IKZF1/3. Recently, their ability to recruit E3 ubiquitin ligase has… Expand
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Total Synthesis of Clavepictines A and B. Diastereoselective Cyclization of δ-Aminoallenes.
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Total Synthesis of Clavepictines A and B. Diastereoselective Cyclization of δ-Aminoallenes
The stereocontrolled total synthesis of (−)-clavepictine A (1A) and (+)-clavepictine B (1B) has been accomplished in an enantioselective fashion, which has unequivocally established the absolute… Expand
  • 58
Novel c-Met inhibitor suppresses the growth of c-Met-addicted gastric cancer cells
Backgroundc-Met signaling has been implicated in oncogenesis especially in cells with c-met gene amplification. Since 20 % of gastric cancer patients show high level of c-Met expression, c-Met has… Expand
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Discovery of aminopyridines substituted with benzoxazole as orally active c-Met kinase inhibitors.
We report the synthesis and biological evaluation of aminopyridines substituted with benzoxazole. The SAR of the aminopyridines was explored to improve the inhibitory activity against c-Met and to… Expand
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Discovery of a novel protein tyrosine phosphatase-1B inhibitor, KR61639: potential development as an antihyperglycemic agent.
Protein tyrosine phosphatase-1B (PTP-1B), a negative regulator of insulin signaling, may be an attractive therapeutic target for type 2 diabetes mellitus. High throughput screening (HTS) for PTP-1B… Expand
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