J. H. Williams

Publications65
h-index23
Citations1,699
Highly Influential Citations47
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Hsp70 release from peripheral blood mononuclear cells.
There are an increasing number of studies reporting the presence of Hsps in human serum. We have investigated the release of Hsp70 into blood and culture medium from peripheral blood mononuclear… Expand
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A novel role for vitamin B(12): Cobalamins are intracellular antioxidants in vitro.
Oxidative stress is a feature of many chronic inflammatory diseases. Such diseases are associated with up-regulation of a vitamin B(12) (cobalamin) blood transport protein and its membrane receptor,… Expand
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Lyn tyrosine kinase is essential for erythropoietin‐induced differentiation of J2E erythroid cells
Erythropoietin stimulates the immature erythroid J2E cell line to terminally differentiate and maintains the viability of the cells in the absence of serum. In contrast, a mutant J2E clone (J2E‐NR)… Expand
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Vitamin B(12) and redox homeostasis: cob(II)alamin reacts with superoxide at rates approaching superoxide dismutase (SOD).
We report a kinetic study of the reaction between superoxide and an important intracellular form of vitamin B(12), cob(II)alamin. Superoxide is implicated in the pathophysiology of many inflammatory… Expand
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Effects of dissociated glucocorticoids on OPG and RANKL in osteoblastic cells.
Glucocorticoids are effective anti-inflammatory and immunosuppressive agents, but their use is often associated with debilitating side effects such as glucocorticoid-induced osteoporosis. Newly… Expand
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Heat shock proteins form part of a danger signal cascade in response to lipopolysaccharide and GroEL
An increasing number of cell types, including peripheral blood mononuclear cells (PBMCs), have been demonstrated to release heat shock proteins (Hsps). In this paper we investigate further the… Expand
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Skeletal muscle calcineurin: influence of phenotype adaptation and atrophy.
Calcineurin (CaN) has been implicated as a signaling molecule that can transduce physiological stimuli (e.g., contractile activity) into molecular signals that initiate slow-fiber phenotypic gene… Expand
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HLS7, a hemopoietic lineage switch gene homologous to the leukemia‐inducing gene MLF1
Hemopoietic lineage switching occurs when leukemic cells, apparently committed to one lineage, change and display the phenotype of another pathway. cDNA representational difference analysis was used… Expand
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Identification of the xanthine oxidase factor as molybdenum.
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Control of barley root respiration
Evidence from barley [Hordeum distichum (L.) Lam. cv. Maris Mink], and from many other species, suggests that respiration is controlled by either supply of carbohydrate or demand for ATP. The… Expand
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