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Blood : textbook of hematology
This edition of the benchmark text is more a complete revitalization than a revision: over 75 per cent of the text and 80 per cent of the references are new. Clearly written and abundantlyExpand
Red Cells Coated with Immunoglobulin G: Binding and Sphering by Mononuclear Cells in Man
TLDR
It is inferred that mononuclear cells have specific surface receptors for immunoglobulin G and that these provide a critical phase of the mechanism in vivo, whereby red cells or other particles coated with antibody are apprehended and destroyed. Expand
Exchange of heme among hemoglobins and between hemoglobin and albumin.
  • H. Bunn, J. H. Jandl
  • Chemistry, Medicine
  • The Journal of biological chemistry
  • 10 February 1968
TLDR
Intact heme groups undergo exchange between molecules of human hemoglobin under physiological conditions, although at equilibrium the affinity of human albumin for ferriheme is only about one-fifteenth that of globin. Expand
Transfer of iron from serum iron-binding protein to human reticulocytes.
Effects of sulfhydryl inhibition on red blood cells. II. Studies in vivo.
TLDR
The results substantiate the existence in human red cells of the glutathione peroxidase mechanism proposed by Mills, whereby GSH protects cellular constituents such as hemoglobin from oxidative damage induced by HzOz. Expand
INCREASED CELL MEMBRANE PERMEABILITY IN THE PATHOGENESIS OF HEREDITARY SPHEROCYTOSIS.
TLDR
The general presumption in studies of HS red cells has been that a deficit existed in their energy metabolism, and evidence has been presented, but later denied, that an abnormality exists in the phospholipids of the red cell membrane in this disease. Expand
Increased susceptibility to infection associated with abnormalities of complement-mediated functions and of the third component of complement (C3).
TLDR
This disorder, which may represent an inborn deficiency of a protein necessary for C3 stability in vivo and in vitro, is detected by the lowered serum C3 concentration and a positive non-gamma (C3) Coombs antiglobulin test. Expand
Oxidative hemolysis and precipitation of hemoglobin. II. Role of thiols in oxidant drug action.
The role of membrane lipids in the survival of red cells in hereditary spherocytosis.
TLDR
HS cells after splenectomy are deficient in both cholesterol and phospholipid, but the transformation to a less spheroidal shape in vivo permits them to traverse better the splenic circulation and survive longer. Expand
The nature of the alpha-methyldopa red-cell antibody.
TLDR
The association of hemolysis with a positive Coombs test implies that the hemolytic process is mediated by antibodies, and, for lack of a clear explanation of the pathogenesis, the process has been regarded by many as "autoimmune". Expand
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