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Hypoxia-Dependent Regulation of Nonphagocytic NADPH Oxidase Subunit NOX4 in the Pulmonary Vasculature
An important role for NOX4 in the vascular remodeling associated with development of pulmonary hypertension is supported by results supported by screening lung tissue for the expression of NADPH oxidase subunits. Expand
Real-time quantitative RT–PCR after laser-assisted cell picking
It is suggested that this new combination of laser-assisted cell picking and real-time PCR has great promise for quantifying mRNA expression in a few single cells or oligocellular clusters in intact organs, allowing assessment of transcriptional regulation in defined cell populations. Expand
Gene expression of natriuretic peptide receptors in myocardial cells.
It is demonstrated that the genes for all three natriuretic peptide receptor (NPR) subtypes,NPR-A, NPR-B, and NPR-C, are expressed in the rat heart and rat ventricular myocytes appear to produce predominantly NPR-A. Expand
NOX4 regulates ROS levels under normoxic and hypoxic conditions, triggers proliferation, and inhibits apoptosis in pulmonary artery adventitial fibroblasts.
NOX4 maintains ROS levels under normoxic and hypoxic conditions and enhances proliferation and inhibits apoptosis of PAFB and a significant increase of NOX4 mRNA expression was observed under hypoxic Conditions in PAFB from the lungs with IPAH compared to healthy donors. Expand
Upregulation of NAD(P)H oxidase 1 in hypoxia activates hypoxia-inducible factor 1 via increase in reactive oxygen species.
It is concluded that hypoxic upregulation of Nox1 and subsequently augmented ROS generation may activate HIF-1-dependent pathways. Expand
HIF-1 alpha signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells.
Fluctuations in cellular oxygenation causing intermittent hypoxia and oxidative stress affect the regulation of hypoxia-inducible factor (HIF-1) and the nuclear factor erythroid 2-related factor 2Expand
Identification of novel Nox4 splice variants with impact on ROS levels in A549 cells.
It is suggested that Nox4 exists as several isoforms that may have different functions in ROS-related cell signaling that are expressed in human lung A549 cell line and lung tissues. Expand
Cellular and molecular mechanisms of hypoxia-inducible factor driven vascular remodeling.
Mechanisms by which HIF interferes with the different vascular remodeling processes are summarized and discussed. Expand
Plasma neuropeptide Y of children with neuroblastoma in relation to stage, age and prognosis, and tissue neuropeptide Y
NPY plasma concentrations in patients with neuroblastoma relate to the stage of the disease, the patients' age, the prognosis, the tumor mRNA expression and with the effect on tumor cell proliferation, which is at the threshold of significance. Expand
RNA interference for HIF-1alpha inhibits its downstream signalling and affects cellular proliferation.
This approach was found to suppress the shift from from S-phase to G1-phase observed in A549 cells in response to hypoxia, supporting a role of HIF-1alpha in oxygen-dependent cell cycle regulation. Expand