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A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed.Expand
A definition of initial, fatty streak, and intermediate lesions of atherosclerosis. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association.
The compositions of lesion types that precede and that may initiate the development of advanced atherosclerotic lesions are described and the possible mechanisms of their development are reviewed.Expand
Metabolic syndrome: definition, pathophysiology, and mechanisms.
TLDR
The definition of metabolic syndrome, the components of the syndrome, and the underlying pathophysiology are addressed, as well as the design of future studies and clinical trials. Expand
A Low-Carbohydrate, Ketogenic Diet versus a Low-Fat Diet To Treat Obesity and Hyperlipidemia
TLDR
Body weight, body composition, serum lipid levels, and adverse effects over 24 weeks in hyperlipidemic persons who were randomly assigned to follow a low-carbohydrate, ketogenic, or low-fat, low-cholesterol, reduced-calorie diet are examined. Expand
Final conclusions and recommendations of the National Lipid Association Statin Safety Assessment Task Force.
This article summarizes the final conclusions of the National Lipid Association (NLA) Statin Safety Task Force, based on a review and independent research of New Drug Application (NDA) information,Expand
Simvastatin and atorvastatin improve behavioral outcome, reduce hippocampal degeneration, and improve cerebral blood flow after experimental traumatic brain injury
TLDR
It is demonstrated that treatment with atorvastatin and simVastatin markedly reduced functional neurological deficits after traumatic brain injury in mice and improved cerebral hemodynamics following head injury, suggesting that the administration of statins may represent a viable therapeutic strategy in the acute treatment of closed head injury. Expand
Efficacy and safety of alirocumab vs ezetimibe in statin-intolerant patients, with a statin rechallenge arm: The ODYSSEY ALTERNATIVE randomized trial.
TLDR
Alirocumab produced greater LDL-C reductions than ezetimibe in statin-intolerant patients, with fewer skeletal-muscle adverse events vs atorvastatin. Expand
Safety considerations with niacin therapy.
TLDR
Clinical evidence since the introduction of statins do not support a general myopathic effect of niacin either alone or in combination with statins, and a valuable medication for cardiovascular risk is underused. Expand
Long-term safety and efficacy of a once-daily niacin/lovastatin formulation for patients with dyslipidemia.
TLDR
Once-daily niacin/lovastatin exhibits substantial effects on multiple lipid risk factors and represents a significant new treatment option in the management of dyslipidemia. Expand
Effectiveness of once-nightly dosing of extended-release niacin alone and in combination for hypercholesterolemia.
TLDR
In the long-term treatment of hypercholesterolemia, Niaspan produced favorable changes in LDL and HDL cholesterol, triglycerides, and lipoprotein(a). Expand
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